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CELSR2 Antibody

  • 货号：
    CSB-PA007949
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9HCU4
  • 基因名：
  • 别名：
    Cadherin EGF LAG seven pass G type receptor 2 flamingo Drosophila homolog antibody; Cadherin EGF LAG seven-pass G-type receptor 2 antibody; Cadherin family member 10 antibody; CDHF10 antibody; CELR2_HUMAN antibody; Celsr2 antibody; EGF like domain multiple 2 antibody; EGF-like protein 2 antibody; EGFL2 antibody; epidermal growth factor like 2 antibody; Epidermal growth factor-like protein 2 antibody; Flamingo homolog 3 antibody; Flamingo1 antibody; KIAA0279 antibody; MEGF3 antibody; Multiple EGF-like domains protein 3 antibody; Multiple epidermal growth factor-like domains 3 antibody; Multiple epidermal growth factor-like domains protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human CDHF10.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor that may have an important role in cell/cell signaling during nervous system formation.
  • 基因功能参考文献：
    1. Both CELSR2 and ING4 display increased cytoplasmic staining in breast cancer cells compared to benign epithelium, suggesting a possible role of both genes in the pathogenesis of human mammary neoplasia. PMID: 29489009
    2. findings suggest a rare variant in CELSR2 as causative for idiopathic scoliosis in a family with dominant segregation and further highlight common variation in CELSR2 in general susceptibility to idiopathic scoliosis in the Swedish-Danish population PMID: 29240829
    3. we report bi-allelic mutations in CELSR2 in a Joubert patient with cortical heterotopia, microophthalmia, and growth hormone deficiency. PMID: 28052552
    4. no association was found between the SNPs of rs599839, rs464218 and rs6698843 at the CELSR2-PSRC1-SORT1 and the risk of coronary artery disease or ischemic stroke PMID: 26464717
    5. CELSR2 in the cholesterol gene cluster shows a significant association with coronary artery disease and its single nucleotide polymorphism regulates plasma cholesterol levels. PMID: 24674750
    6. The novel CAD-associated locus in the vicinity of the PSRC1 and CELSR2 genes on chromosome 1 probably enhances CAD risk through an effect on plasma LDL cholesterol. PMID: 18649068

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family, LN-TM7 subfamily
  • 组织特异性：
    Highest expression in brain and testis.
  • 数据库链接：

    HGNC: 3231

    OMIM: 604265

    KEGG: hsa:1952

    STRING: 9606.ENSP00000271332

    UniGene: Hs.57652