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CDKL2 Antibody

  • 货号：
    CSB-PA070198
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q92772
  • 基因名：
    CDKL2
  • 别名：
    CDKL2Cyclin-dependent kinase-like 2 antibody; EC 2.7.11.22 antibody; Protein kinase p56 KKIAMRE antibody; Serine/threonine-protein kinase KKIAMRE antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human KKIAMRE.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. Results showed that the methylation levels of CDKL2 were higher in hepatocellular carcinoma (HCC) cell lines and tissues but the mRNA expression levels decreased both in HCC tissues and cell lines. CDKL2 status seems to correlate with tumor size and may play an important role in hepatocarcinogenesis. PMID: 30292871
    2. High CDKL2 promotes epithelial-mesenchymal transition and breast cancer progression. PMID: 25333262
    3. We hypothesized that LA might induce dissociation of p56(Lck) from CD4, thus leading to its downmodulation. PMID: 16631599
  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 组织特异性：
    Expressed in testis and kidney, and at lower level in brain and lung.
  • 数据库链接：

    HGNC: 1782

    OMIM: 603442

    KEGG: hsa:8999

    STRING: 9606.ENSP00000412365

    UniGene: Hs.591698