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CDK5RAP1 Antibody

  • 货号：
    CSB-PA030018
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q96SZ6
  • 基因名：
    CDK5RAP1
  • 别名：
    CDK5RAP1 antibody; C20orf34 antibody; CGI-05 antibody; HSPC167CDK5 regulatory subunit-associated protein 1 antibody; CDK5 activator-binding protein C42 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CDK5 Activator-binding C42.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Methylthiotransferase that catalyzes the conversion of N6-(dimethylallyl)adenosine (i(6)A) to 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 (adjacent to the 3'-end of the anticodon) of four mitochondrial DNA-encoded tRNAs (Ser(UCN), Phe, Tyr and Trp). Essential for efficient and highly accurate protein translation by the ribosome. Specifically inhibits CDK5 activation by CDK5R1. Essential for efficient mitochondrial protein synthesis and respiratory chain; shows pathological consequences in mitochondrial disease.
  • 基因功能参考文献：
    1. The mitochondrial localization of ms2i6A modification was diminished in HeLa cells when transfected with siRNA against Cdk5 regulatory subunit-associated protein 1 (Cdk5rap1), suggesting that the modification occurs in tRNAs in mitochondria. PMID: 28981754
    2. Which resulted in respiratory defects in Cdk5rap1 knockout (KO) mice. PMID: 25738458
    3. data indicated that CDK5RAP1 deficiency induced cell cycle arrest and apoptosis in human breast cancer PMID: 25607831
    4. CDK5RAP1 may be a risk factor of vitiligo in the Korean population PMID: 22534366
    5. CDK5RAP1 is a radical SAM enzyme, which postsynthetically converts the RNA modification N6-isopentenyladenosine into 2-methylthio-N6-isopentenyladenosine. PMID: 22422838

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  • 亚细胞定位：
    Mitochondrion.
  • 蛋白家族：
    Methylthiotransferase family, MiaB subfamily
  • 组织特异性：
    Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Expressed in neurons of central nervous tissue.; [Isoform 5]: Mainly expressed in brain, placenta and testis.; [Isoform 6]: High expression in placenta and lung.
  • 数据库链接：

    HGNC: 15880

    OMIM: 608200

    KEGG: hsa:51654

    STRING: 9606.ENSP00000217372

    UniGene: Hs.435952