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  4. CDK20 Antibody

CDK20 Antibody

  • 中文名称：
    CDK20兔多克隆抗体
  • 货号：
    CSB-PA008397
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q8IZL9
  • 基因名：
    CDK20
  • 别名：
    CAK kinase p42 antibody; CAK-kinase p42 antibody; CCRK antibody; CDCH antibody; CDK activating kinase p42 antibody; CDK-activating kinase p42 antibody; cdk20 antibody; CDK20_HUMAN antibody; Cell cycle related kinase antibody; Cell cycle-related kinase antibody; Cell division protein kinase 20 antibody; Cyclin dependent protein kinase H antibody; Cyclin kinase activating kinase p42 antibody; Cyclin-dependent kinase 20 antibody; Cyclin-dependent protein kinase H antibody; Cyclin-kinase-activating kinase p42 antibody; p42 antibody; PNQALRE antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CCRK.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling. Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.
  • 基因功能参考文献：
    1. Results delineate an immunosuppressive mechanism of the hepatoma-intrinsic CCRK signalling and highlight an overexpressed kinase target whose inhibition might empower hepatocellular carcinoma immunotherapy PMID: 28939663
    2. A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patient. PMID: 25500144
    3. Data indicate that expression of ERAS, LHX1, and CCRK is increased in aggressive subgroups of medulloblastomas. PMID: 22875024
    4. Cell cycle-related kinase is a direct androgen receptor-regulated gene that drives beta-catenin/T cell factor-dependent hepatocarcinogenesis PMID: 21747169
    5. results suggest for the first time that CCRK is involved in colorectal cancer carcinogenesis and G1/S cell cycle transition by regulating Cdk2, cyclin E and Rb. PMID: 20466538
    6. identification of p42, a novel cyclin-dependent kinase-activating kinase (CAK) activity in human cells; p42 is essential for the phosphorylation of Thr-160 and activation of CDK2 and is indispensable for cell growth PMID: 14597612
    7. Depletion of PNQALRE by >80% due to RNA interference (RNAi) impairs cell proliferation, but fails to arrest the cell cycle at a discrete point. PMID: 16552187
    8. Overexpression of CCRK is associated with ovarian carcinoma. PMID: 19672860

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  • 亚细胞定位：
    Nucleus. Cytoplasm. Cell projection, cilium.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 数据库链接：

    HGNC: 21420

    OMIM: 610076

    KEGG: hsa:23552

    STRING: 9606.ENSP00000322343

    UniGene: Hs.522274