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  4. CDK16 Antibody

CDK16 Antibody

  • 货号：
    CSB-PA017648GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q00536
  • 基因名：
    CDK16
  • 别名：
    Cdk16 antibody; CDK16_HUMAN antibody; Cell division protein kinase 16 antibody; Cyclin-dependent kinase 16 antibody; PCTAIRE antibody; PCTAIRE protein kinase 1 antibody; PCTAIRE-motif protein kinase 1 antibody; PCTAIRE1 antibody; PCTGAIRE antibody; PCTK1 antibody; Serine/threonine-protein kinase PCTAIRE-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human PCTK1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Regulates GH1 release by brain neurons. Phosphorylates NSF, and thereby regulates NSF oligomerization. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development. Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Can phosphorylate CCNY at 'Ser-336' (in vitro).
  • 基因功能参考文献：
    1. CDK16 negatively modulates p53 signaling pathway to promote radioresistance in lung cancer cells. PMID: 29344296
    2. CDK16 is significantly up-regulated in non-small cell lung cancer tumor tissue and plays a role in promoting cell proliferation. PMID: 29674275
    3. s provided the first evidence that CDK16 is an bona fide oncogene in HCC, and multiple activating mechanisms at transcriptional and posttranscriptional levels together contributes to CDK16 up-regulation in HCC. PMID: 28716136
    4. CDK-16 upregulation in serous EOC cells may represent a negative feedback loop to promote ovarian cell differentiation in malignantly-transformed serous epithelial ovarian cancer cells PMID: 26546806
    5. GALNT7 and CDK16 were confirmed to be the direct targets of miR-494. These results suggested that miR-494 play an inhibitory role in the tumorigenesis of NPC PMID: 25809707
    6. Activation of PCTAIRE-1 is mediated through interaction with the phosphorylated form of cyclin Y in complex with 14-3-3. PMID: 26205494
    7. An unexpected role for PCTAIRE1 in regulating p27 stability, mitosis, and tumor growth. PMID: 25205104
    8. Dysfunction of MKL2 and its transcriptional coactivation partner, serum response factor (SRF), was supported by a decrease in gene and protein expression of PCTAIRE1, a downstream target of MKL2:SRF heterodimer transcriptional activation PMID: 23692340
    9. Pctaire1 exerts promyogenic effects by regulating myoblast migration and process formation during skeletal myogenesis PMID: 24931367
    10. a novel function of BRSK2 in the regulation of GSIS in beta-cells via a PCTAIRE1-dependent mechanism and suggest that BRSK2 is an attractive target for developing novel diabetic drugs. PMID: 22798068
    11. CCNY binding to CDK16 required a region upstream of the kinase domain and was found to be inhibited by phosphorylation of serine 153, a potential PKA phosphorylation site. PMID: 22184064
    12. Cdk5-dependent phosphorylation of Pctaire1 at Ser95 plays an important role in dendrite development PMID: 21335063
    13. Data show that various forms of PCTAIRE-1 transfected into neuroblastoma cell lines could either promote or inhibit neurite outgrowth, suggesting a potential role for the PCTAIRE-1 gene product in the control of neurite outgrowth. PMID: 12154078

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  • 亚细胞定位：
    Cytoplasm. Cytoplasmic vesicle, secretory vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse, synaptosome. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 组织特异性：
    Detected in pancreas islets (at protein level). Detected in brain and pancreas.
  • 数据库链接：

    HGNC: 8749

    OMIM: 311550

    KEGG: hsa:5127

    STRING: 9606.ENSP00000276052

    UniGene: Hs.496068