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CDK10 Antibody

  • 货号：
    CSB-PA005060ESR2HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA005060ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA005060ESR2HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CDK10 Polyclonal antibody
  • Uniprot No.：
    Q15131
  • 基因名：
    CDK10
  • 别名：
    CDC2 related protein kinase antibody; Cdk10 antibody; CDK10_HUMAN antibody; Cell division protein kinase 10 antibody; Cyclin dependent kinase 10 antibody; Cyclin dependent kinase related protein antibody; Cyclin-dependent kinase 10 antibody; PISSLRE antibody; Serine/threonine protein kinase PISSLRE antibody; Serine/threonine-protein kinase PISSLRE antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cyclin-dependent kinase 10 protein (1-283AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.
  • 基因功能参考文献：
    1. The present study illustrated that downregulation of CDK10 expression activated Snaildriven EMT and consequently promoted glioma metastasis, suggesting that CDK10 may serve as a potential molecular target for glioma therapy. PMID: 29845196
    2. the results of the present study indicated that CDK10 expression may serve as a novel prognostic biomarker that holds therapeutic promise for gastric cancer. PMID: 29512714
    3. The findings of this study indicate that CDK10 plays a role in the pathogenesis in colorectal cancer and may be a potential therapeutic target for treatment. PMID: 28663269
    4. These findings underscore the importance of CDK10 for the regulation of ciliogenesis. CDK10 defect is likely associated with a new form of ciliopathy phenotype; additional patients may further validate this association PMID: 29130579
    5. CDK10 Mutations are associated with Severe Growth Retardation, Spine Malformations, and Developmental Delays. PMID: 28886341
    6. CDK10/CycM is a key regulator of actin dynamics and a suppressor of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling. PMID: 27104747
    7. Down-regulated CDK10 expression frequently occurs in breast cancers and correlates with disease progression and poor survival PMID: 26392360
    8. Results found that CDK10 mRNA expression was up-regulated in advanced breast neoplasm and positively correlated with C1orf63, which was consistent with the relationship of protein expression between C1orf63 and CDK10. PMID: 26209438
    9. Data suggest that reactivation of CDK10 might be utilized as a novel epigenetic strategy for the treatment of nasopharyngeal carcinomas (NPC) patients. PMID: 23740091
    10. CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome. PMID: 24218572
    11. Data show that peptidyl-prolyl isomerase Pin1 silencing in SKBR-3 and MCF7 cells increased the cyclin-dependent kinase 10 (CDK10) expression. PMID: 22158035
    12. CDK10 plays a crucial role in the growth and survivability of biliary tract cancer. PMID: 22209942
    13. reduced Cdk10 expression is closely linked to hepatocellular carcinoma development and progression PMID: 22326270
    14. CDK10 is not a target for aberrant DNA methylation in breast cancer. PMID: 19846932

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  • 相关疾病：
    Al Kaissi syndrome (ALKAS)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, cilium basal body.
  • 蛋白家族：
    Protein kinase superfamily, CMGC Ser/Thr protein kinase family, CDC2/CDKX subfamily
  • 数据库链接：

    HGNC: 1770

    OMIM: 603464

    KEGG: hsa:8558

    STRING: 9606.ENSP00000338673

    UniGene: Hs.699177