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CDC42BPB Antibody

  • 货号：
    CSB-PA936608
  • 规格：
    ￥2024
  • 图片：
    • Western blot analysis of extracts from COLO cells, using MRCKB antibody.
    • Immunohistochemistry analysis of paraffin-embedded human brain tissue using MRCKB antibody.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CDC42BPB Polyclonal antibody
  • Uniprot No.：
    Q9Y5S2
  • 基因名：
    CDC42BPB
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human MRCKB.
  • 免疫原种属：
    Homo sapiens (Human)
  • 克隆类型：
    Polyclonal
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A. In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation.
  • 基因功能参考文献：
    1. these results provide further validation for MRCK involvement in regulation of cancer cell invasion. PMID: 21949762
    2. Cdc42-dependent formation of the ZO-1/MRCKbeta complex at the leading edge controls cell migration. PMID: 21240187
    3. Q-PCR results demonstrated VH2 genes were overexpressed in ankylosing spondylitis patients. The sequence analysis revealed the majority of them contained CDC42 binding protein kinase Beta (CDC42 BPB) genes. PMID: 20177145
  • 亚细胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction. Cell projection, lamellipodium.
  • 蛋白家族：
    Protein kinase superfamily, AGC Ser/Thr protein kinase family, DMPK subfamily
  • 组织特异性：
    Expressed in all tissues examined, with high levels in heart, brain, placenta and lung.
  • 数据库链接：

    HGNC: 1738

    OMIM: 614062

    KEGG: hsa:9578

    STRING: 9606.ENSP00000355237

    UniGene: Hs.654634