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CDC23 Antibody

  • 货号：
    CSB-PA001498
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COS7 cells using Cdc23 Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 cells using Cdc23 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9UJX2
  • 基因名：
  • 别名：
    ANAPC8 antibody; Anaphase promoting complex subunit 8 antibody; Anaphase-promoting complex subunit 8 antibody; Apc 8 antibody; APC8 antibody; Cdc 23 antibody; CDC23 antibody; CDC23_HUMAN antibody; cell division cycle 23 antibody; Cell division cycle 23 homolog antibody; Cell division cycle protein 23 antibody; Cell division cycle protein 23 homolog antibody; Cut23 antibody; Cyclosome subunit 8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Monkey
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Cdc23.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • 基因功能参考文献：
    1. Results identified CDC23 as a miR-34c-regulated target that could be responsible for the miR-34c-induced cell cycle arrest. PMID: 25064703
    2. CDC23 is a critical regulator of cell cycle and cell growth, may be involved in thyroid cancer initiation and progression, and may explain the different tumor biology observed by gender. PMID: 21990323
    3. Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A PMID: 21336306
    4. We report gene alterations in several components of this complex in human colon cancer cells, including APC6/CDC16 and APC8/CDC23 which are known to be key function elements. PMID: 12629511
  • 蛋白家族：
    APC8/CDC23 family
  • 数据库链接：

    HGNC: 1724

    OMIM: 603462

    KEGG: hsa:8697

    STRING: 9606.ENSP00000378350

    UniGene: Hs.73625