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CDAN1 Antibody

  • 货号：
    CSB-PA810285LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA810285LA01HU diluted at 1:300 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA810285LA01HU diluted at 1:300 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of SH-SY5Y cells with CSB-PA810285LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CDAN1 Polyclonal antibody
  • Uniprot No.：
    Q8IWY9
  • 基因名：
    CDAN1
  • 别名：
    CDA1 antibody; CDAI antibody; CDAN1 antibody; CDAN1_HUMAN antibody; Codanin antibody; Codanin-1 antibody; Codanin1 antibody; PRO1295 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Codanin-1 protein (62-249AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CDAN1 Antibody (CSB-PA810285LA01HU)，的标记方式是Non-conjugated。对于CDAN1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA810285LB01HU CDAN1 Antibody, HRP conjugated ELISA
    FITC CSB-PA810285LC01HU CDAN1 Antibody, FITC conjugated
    Biotin CSB-PA810285LD01HU CDAN1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May act as a negative regulator of ASF1 in chromatin assembly.
  • 基因功能参考文献：
    1. Mutation in CDAN1 gene is associated with congenital dyserythropoietic anemia. PMID: 29031773
    2. The missense substitution in CDAN1, C15ORF41, encodes a novel restriction endonuclease in congenital dyserythropoietic anemia type I. PMID: 23716552
    3. The proband with congenital dyserythropoietic anemia Iota in the first family was a compound heterozygote of CDAN1 with mutation IVS-12+2T>C and c. 3389C>T. PMID: 24196372
    4. The s propose that Codanin-1 acts as a negative regulator of Asf1 function in chromatin assembly. PMID: 22407294
    5. A link between mutant codanin-1 and the aberrant localization of HP1 alpha is supported by the finding that codanin-1 can be coimmunoprecipitated by anti-HP1 alpha antibodies erythroblasts from patients with congenital dyserythropoietic anemia type 1. PMID: 21364188
    6. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1 PMID: 12434312
    7. codanin-1 may play a role in the development of the skeleton. PMID: 16767397
    8. This second case of retinal angioid streaks in CDA I reports a patient homozygous for the Arg1042Trp mutation in codanin-1. PMID: 18081704
    9. Congenital dyserythropoietic anemia I (CDA I) is a well-defined entity within the heterogeneous group of the CDAN1 family; here it is associated with mutations in a Chinese family. PMID: 18575862
    10. Data suggest that codanin-1 is a cell cycle-regulated protein active in the S phase. PMID: 19336738

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  • 相关疾病：
    Anemia, congenital dyserythropoietic, 1A (CDAN1A)
  • 亚细胞定位：
    Cytoplasm. Nucleus. Membrane; Multi-pass membrane protein. Note=Mainly detected as a cytoplasmic protein.
  • 组织特异性：
    Ubiquitously expressed. Isoform 3 is not found in erythroid cells.
  • 数据库链接：

    HGNC: 1713

    OMIM: 224120

    KEGG: hsa:146059

    STRING: 9606.ENSP00000348564

    UniGene: Hs.599232