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CD101 Antibody

  • 中文名称：
    CD101兔多克隆抗体
  • 货号：
    CSB-PA006234
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of MOUSE-BRAIN cells using CD101 Polyclonal Antibody
    • Western Blot analysis of mouse brain cells using CD101 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q93033
  • 基因名：
    CD101
  • 别名：
    CD101 antibody; EWI101 antibody; IGSF2 antibody; V7Immunoglobulin superfamily member 2 antibody; IgSF2 antibody; Cell surface glycoprotein V7 antibody; Glu-Trp-Ile EWI motif-containing protein 101 antibody; EWI-101 antibody; CD antigen CD101 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CD101.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.
  • 基因功能参考文献：
    1. Study shows nucleotide substitutions in CD101, the human homolog of a diabetes susceptibility gene in non-obese diabetic mouse, in patients with type 1 diabetes. The results raise the possibility that CD101 is a susceptibility gene for type 1 diabetes. PMID: 27888582
    2. In patients with intestinal bowel disease, a reduced CD101 expression on peripheral and intestinal monocytes and CD4-positive Tcells correlated with enhanced IL-17 production and disease activity. PMID: 26813346
    3. Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease. PMID: 25421756
    4. Single Nucleotide Polymorphism in CD101 gene may be associated with pancreatic cancer. PMID: 21467233
    5. Results suggest a possible role for CD101 expression and function in the control of certain manifestations of rheumatoid arthritis pathology. PMID: 21159825

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tu
  • 数据库链接：

    HGNC: 5949

    OMIM: 604516

    KEGG: hsa:9398

    STRING: 9606.ENSP00000256652

    UniGene: Hs.654598