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CCR10 Antibody

  • 货号：
    CSB-PA004840LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA004840LA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA004840LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, HepG2 whole cell lysate
      All lanes: CCR10 antibody at 2.7µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 39 kDa
      Observed band size: 39 kDa
  • 其他：

产品详情

  • 产品描述：

    The recombinant human C-C chemokine receptor type 10 (CCR10) protein (314-362AA) is used to immunize rabbits to obtain the CCR10 antibody. This CCR10 polyclonal antibody exists as an unconjugated IgG. It has undergone protein G purification and reaches up to 95% in purity. It only shows reactivity with human CCR10 protein. Quality tests of this antibody have been validated in ELISA, WB, IHC, and IF assays. The target protein CCR10 is the receptor for CCL27 and CCL28. CCR10 interacting with CCL27 is involved in T cell-mediated skin inflammation. CCR10/CCL28 interactions are essential for efficient accumulation of antigen-specific IgA plasma cells to the murine large intestine and mammary gland.

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CCR10 Polyclonal antibody
  • Uniprot No.：
    P46092
  • 基因名：
  • 别名：
    CCR10; GPR2; C-C chemokine receptor type 10; C-C CKR-10; CC-CKR-10; CCR-10; G-protein coupled receptor 2
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human C-C chemokine receptor type 10 protein (314-362AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CCR10 Antibody (CSB-PA004840LA01HU)，的标记方式是Non-conjugated。对于CCR10 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004840LB01HU CCR10 Antibody, HRP conjugated ELISA
    FITC CSB-PA004840LC01HU CCR10 Antibody, FITC conjugated
    Biotin CSB-PA004840LD01HU CCR10 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:200-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.
  • 基因功能参考文献：
    1. CCR10 may be a key regulator in breast cancer cell invasion and migration PMID: 28830025
    2. CCR10/CCL27 crosstalk mediated drug resistance, contributing to failure of proteasome-inhibitors in multiple myeloma. PMID: 27732933
    3. CCL27 drives baseline recruitment of Herpes simplex virus-specific CD8 T cells expressing CCR10, while interferon-responsive CXCR3 ligands recruit additional cells in response to virus-driven inflammation. PMID: 28701399
    4. The chemokine receptor CCR10 is highly expressed in human glioblastoma compared with control brain tissue. PMID: 25149529
    5. Findings support the notion that CCR10 and its ligand CCL27 may contribute to the skin infiltration of malignant T-cells in mycosis fungoides and adult T-cell leukemia/lymphoma. PMID: 24970722
    6. low CCL27/CCR10 and CXCL12/CXCR4 intratumoral mRNA ratios are associated with melanoma progression PMID: 22526457
    7. CCR7 overexpression correlated with expression of metallothionein, while CCR10 was associated with cerebral metastases. CCR7 and CCR10 overexpressions were associated with a worse outcome independent of Breslow's tumor thickness and Clark level. PMID: 22350183
    8. unlike blood plasmacytoid dendritic cells (pDCs), a subset of tonsil pDCs express functional CCR6 and CCR10, and their respective ligands CCL20 and CCL27 are detected in inflamed epithelia PMID: 21937703
    9. The high fraction of circulating IgA+ and IgG+ B cells expressing CCR9 and CCR10 in the first months of life indicates activation of naive B cells in the gut, coinciding with bacterial colonization. PMID: 21075690
    10. TLR2 ligands induce CCR9 and CCR10 expression by circulating B-cells and increase their chemotaxis. TLR2 stimulation also induced J chain and IgA production demonstrating the induction of mucosal-like antibody secreting cells. PMID: 20947433
    11. CCR10 and its ligand CCL27 may contribute to the skin infiltration of malignant T-cells in cutaneous T-cell lymphoma. PMID: 15700309
    12. gene expression of CCR10 was increased by recombinant ANXA1 and the N-terminal ANXA1 peptide PMID: 16460738
    13. CCR10-CTACK/CCL27 interactions between circulating T cells and keratinocytes would seem to play an important role in the pathophysiology of mycosis fungoides. PMID: 16675558
    14. CCR10 allows T regulatory (Treg) cells recruited to chronically inflamed liver tissues to respond to CCL28 secreted by epithelial cells, resulting in the accumulation of CCR10+ Tregs at mucosal surfaces. PMID: 16785557
    15. CCR4 and CCR10 may play an important role in ATLL invasion into the skin PMID: 17071491
    16. CCR4 and CCR10 are expressed on epidermal keratinocytes and that both are functional in terms of skin cytokine production and/or migration to their ligand CCL17 and CCL27, respectively. PMID: 18782672

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed at high levels in adult testis, small intestine, fetal lung, fetal kidney. Weaker expression was observed in many other adult tissues including spleen, thymus, lymph node, Peyer patches, colon, heart, ovary, peripheral blood lymphocytes, thyroid
  • 数据库链接：

    HGNC: 4474

    OMIM: 600240

    KEGG: hsa:2826

    STRING: 9606.ENSP00000332504

    UniGene: Hs.744542