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CCNO Antibody

  • 货号：
    CSB-PA004831LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA004831LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA004831LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA004831LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CCNO Polyclonal antibody
  • Uniprot No.：
    P22674
  • 基因名：
    CCNO
  • 别名：
    CCNO antibody; CCNO_HUMAN antibody; CCNU antibody; Cyclin domain containing antibody; Cyclin like uracil DNA glycosylase antibody; Cyclin O antibody; Cyclin U antibody; Cyclin-O antibody; DGU antibody; EC 3.2.2. antibody; UDG2 antibody; UNG2 antibody; Uracil DNA glycolylase 2 antibody; Uracil DNA glycosylase cyclin like antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Cyclin-O protein (1-257AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CCNO Antibody (CSB-PA004831LA01HU)，的标记方式是Non-conjugated。对于CCNO Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004831LB01HU CCNO Antibody, HRP conjugated ELISA
    FITC CSB-PA004831LC01HU CCNO Antibody, FITC conjugated
    Biotin CSB-PA004831LD01HU CCNO Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking.
  • 基因功能参考文献：
    1. This study presents the crystal structure of the DDB1-DCAF1-HIV-1-Vpr-uracil-DNA glycosylase (cyclin U) complex. PMID: 27571178
    2. CCNO is mutated more frequently than expected from the rare previous clinical case reports, leads to severe clinical manifestations, and should therefore be considered an important differential diagnosis of mucociliary clearance disorders. PMID: 26777464
    3. CCNO mutations have a role in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia PMID: 24747639
    4. This publication corrected the mistaken attribution of uracil DNA glycosylase activity to this gene. PMID: 8419333
    5. This publication initially attributed 'uracil-DNA glycosylase' activity to this gene and named it UNG2, but a later publication (PubMed ID: 8419333) more correctly identified UNG2/CCNO as a member of the cyclin protein family. PMID: 2001396

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  • 相关疾病：
    Ciliary dyskinesia, primary, 29 (CILD29)
  • 亚细胞定位：
    Cytoplasm. Nucleus, nucleolus.
  • 蛋白家族：
    Cyclin family
  • 组织特异性：
    Present in respiratory cells (at protein level).
  • 数据库链接：

    HGNC: 18576

    OMIM: 607752

    KEGG: hsa:10309

    STRING: 9606.ENSP00000282572

    UniGene: Hs.3041