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  4. CCNDBP1 Antibody

CCNDBP1 Antibody

  • 货号：
    CSB-PA004816GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O95273
  • 基因名：
    CCNDBP1
  • 别名：
    AU022347 antibody; CCDB1_HUMAN antibody; CCNDBP 1 antibody; Ccndbp1 antibody; Cyclin D type binding protein 1 antibody; Cyclin-D1-binding protein 1 antibody; D type cyclin interacting protein 1 antibody; DIP 1 antibody; DIP1 antibody; GCIP antibody; Grap 2 and cyclin D interacting protein antibody; Grap 2 cyclin D interacting protein GCIP antibody; Grap 2 cyclin interacting protein antibody; Grap2 and cyclin D interacting protein antibody; Grap2 and cyclin-D-interacting protein antibody; Grap2 cyclin D interacting protein GCIP antibody; Grap2 cyclin interacting protein antibody; HHM antibody; HHM protein antibody; Human homolog of Maid antibody; MAID antibody; MAID protein antibody; Maternal inhibition of differentiation antibody; MGC109078 antibody; OTTMUSP00000017037 antibody; RP23 263D22.2 antibody; SECC 8 antibody; SSEC 8 antibody; Stage specific embryonic cDNA 8 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CCNDBP1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription.
  • 基因功能参考文献：
    1. Data suggest MAID/CCNDBP1 inhibits cell migration induced by TGFB1 (transforming growth factor-beta1) but not by BMP4 (bone morphogenetic protein-4); MAID does not alter cell proliferation, epithelial-mesenchymal transition, or TGFB3-induced apoptosis. PMID: 26002959
    2. GCIP underexpression is associated with Osteosarcoma. PMID: 26107195
    3. Data indicate that grap2 and cyclin D1 interacting protein (GCIP) and inhibitor of of DNA binding/differentiation 1 (Id1) are inversely expressed in non-small cell lung cancer (NSCLC) cell lines and specimens. PMID: 24970809
    4. The first structure of a free-standing human dominant-negative helix-loop-helix protein (DIP1) was reported. DIP1 adopts a V-shaped conformation, with N-terminal and C-terminal five-helix bundles connected by the HLH region. PMID: 22453338
    5. It is proposed for the first time that Rad may promote carcinogenesis at least in part by inhibiting GCIP-mediated tumor suppression. PMID: 20460530
    6. In transgenic mice, GCIP functions as a transcriptional suppressor, regulates cyclin D1 expression, inhibits cell growth and colony formation in human HepG2 cells, suggesting GCIP plays a significant role in tumor initiation and development. PMID: 16501603
    7. CT847 interacts with mammalian Grap2 cyclin D-interacting protein PMID: 17532760
    8. P0 overexpression may cause tumorigenesis in breast and liver tissues at least in part by inhibiting GCIP-mediated tumor suppression. PMID: 17621266
    9. Data suggest that HHM/Maid regulates a subset of TGF-beta target genes including the Olig1-Smad synexpression group. PMID: 18923419
    10. decreased expression of GCIP in vivo is present in human breast carcinoma. PMID: 18983464
    11. Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator PMID: 19153449

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CCNDBP1 family
  • 组织特异性：
    Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas.
  • 数据库链接：

    HGNC: 1587

    OMIM: 607089

    KEGG: hsa:23582

    STRING: 9606.ENSP00000300213

    UniGene: Hs.36794