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CCNB1IP1 Antibody

  • 货号：
    CSB-PA002899
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of COLO205 cells using HEI10 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9NPC3
  • 基因名：
    CCNB1IP1
  • 别名：
    C14orf18 antibody; CCNB1IP1 antibody; Chromosome 14 open reading frame 18 antibody; CIP1_HUMAN antibody; Cyclin B1 interacting protein 1 antibody; cyclin B1 interacting protein 1; E3 ubiquitin protein ligase antibody; Cyclin-B1-interacting protein 1 antibody; E3 ubiquitin-protein ligase CCNB1IP1 antibody; Enhancer of invasion 10 antibody; Gm288 antibody; HEI10 antibody; Human enhancer of invasion 10 antibody; mei4 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human HEI10.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.; E3 ubiquitin-protein ligase. Modulates cyclin B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
  • 基因功能参考文献：
    1. HEI10 defines a divergent class of E3 ubiquitin ligase, functioning in progression through G(2)/M. PMID: 12612082
    2. The cyclin B-binding protein and cell cycle regulator HEI10 is identified as a novel merlin-binding partner; interaction with merlin affects HEI10 protein levels. PMID: 16532029
  • 亚细胞定位：
    Nucleus. Chromosome. Note=Associates to the synaptonemal complex.
  • 组织特异性：
    Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.
  • 数据库链接：

    HGNC: 19437

    OMIM: 608249

    KEGG: hsa:57820

    STRING: 9606.ENSP00000337396

    UniGene: Hs.107003