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CCL15 Antibody

  • 货号：
    CSB-PA784761
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200
  • 其他：

产品详情

  • Uniprot No.：
    Q16663
  • 基因名：
  • 别名：
    C-C motif chemokine 15 antibody; C-C motif chemokine ligand 15 antibody; CC chemokine 3 antibody; CCL15 antibody; CCL15(29-92) antibody; CCL15_HUMAN antibody; Chemokine (C C motif) ligand 15 antibody; Chemokine CC-2 antibody; Chemokine CC2 antibody; HCC-2 antibody; HCC2 antibody; HMRP 2B antibody; HMRP2B antibody; Leukotactin 1 antibody; Leukotactin-1 antibody; LKN-1 antibody; LKN1 antibody; Macrophage inflammatory protein 5 antibody; MIP 1D antibody; MIP-1 delta antibody; MIP-1D antibody; MIP-5 antibody; MIP1 delta antibody; MIP1d antibody; MIP5 antibody; MRP 2B antibody; Mrp-2b antibody; Mrp2b antibody; NCC 3 antibody; NCC-3 antibody; NCC3 antibody; New CC chemokine 3 antibody; OTTHUMP00000163955 antibody; SCYA15 antibody; SCYL3 antibody; Small inducible cytokine A15 antibody; Small inducible cytokine subfamily A (Cys Cys); member 15 antibody; Small-inducible cytokine A15 antibody; SY15 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 51-100
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.
  • 基因功能参考文献：
    1. CCL15 secreted from SMAD4-deficient xenografted human colorectal cancer cells recruited CCR1(+) cells, promoting their metastatic activities to the lung. Lung metastases from colorectal cancer patients revealed that CCL15 expression correlated with loss of SMAD4. CCL15-positive metastases recruited approximately 1.9 times more numbers of CCR1(+) cells than CCL15-negative metastases. PMID: 27492974
    2. CCL15 activation of CCR1 plays critical roles in hepatocellular carcinoma metastasis. PMID: 26501423
    3. Orthotopic animal models of HCC were established to investigate the role of CCL15 in hMSCs migration toward HCC in vivo. Both histological and flow cytometric analysis showed that significantly fewer hMSCs localized within 97H-CCL15-shRNA xenografts compared with 97H-green fluorescent protein xenografts after intravenous delivery PMID: 26763650
    4. Loss of SMAD4 was significantly associated with CCL15 expression. PMID: 26341919
    5. follicular thyroid carcinoma (FTC) might induce tumor associated macrophages (TAMs) infiltration by producing CCL15. Measurement of TAMs and CCL15 in follicular thyroid lesions may be applied clinically to differentiate FTC from follicular adenoma PMID: 26875556
    6. two inflammatory cytokines, MIP-1delta and MIP-3alpha, are able to increase mesenchymal stromal cells migration in vitro PMID: 25579056
    7. we investigated a role of CCL15 in upregulating ICAM-1 in endothelial cells PMID: 23690481
    8. CCL15 is elevated in human asthma and correlates with disease severity . PMID: 22092970
    9. Data show that Only three of these proteins EGF, PDGF-BB and MIP-1delta (CCL15) differed significantly in plasma between controls and Alzheimer's disease (AD). PMID: 22279551
    10. increased secretion by macrophages during Mycobacterium tuberculosis infection PMID: 20016943
    11. truncation of NH2-terminal amino acid residues increases agonistic potency on CC chemokine receptors 1 and 3 PMID: 11832479
    12. Lkn-1 activates the ERK pathway by transducing the signal through G(i)/G(o) protein, PLC, PKC delta and Ras, and it may play a role for cell proliferation, differentiation, and regulation of gene expression for other cellular processes PMID: 12759139
    13. These observations demonstrate that the two NF-kappaB binding sites are essential for phorbol myristate acetate-induced leukotactin-1 (Lkn-1)/CCL15 expression in human monocytes. PMID: 15179048
    14. CCL15(25-92) has in vitro and in vivo angiogenic activity PMID: 15251437
    15. alanine-aspartic acid residues preceding the first cysteine at the NH(2)-terminus are essential for the binding and biological activity of leukotactin-1 PMID: 15894113
    16. Compared with full-length CCL15, proteolytically processed CCL15 isoforms with N-terminal deletions display increased potency to induce calcium fluxes and chemotactic activity on monocytes and to induce adhesiveness of mononuclear cells to fibronectin. PMID: 16034099
    17. Transcription of the CCL15 gene is regulated by AP-1 and NF-kappaB through MEK and JNK MAPK pathways in monocytoid cells. PMID: 16364464
    18. Results point to an involvement of the CCL15-CCR1 axis in the pathophysiology of chronic renal failure. PMID: 16737685
    19. factor NF-kappaB plays an important role in regulation of LZIP expression, and LZIP expression regulates the monocyte cell migration induced by Lkn-1 PMID: 17296613

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 组织特异性：
    Most abundant in heart, skeletal muscle and adrenal gland. Lower levels in placenta, liver, pancreas and bone marrow. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are found in high levels in synovial fluids from rheumatoid patients.
  • 数据库链接：

    HGNC: 10613

    OMIM: 601393

    KEGG: hsa:6359

    STRING: 9606.ENSP00000432034

    UniGene: Hs.272493