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CBR4 Antibody

  • 货号：
    CSB-PA850803ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA850803ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA850803ESR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CBR4 Polyclonal antibody
  • Uniprot No.：
    Q8N4T8
  • 基因名：
    CBR4
  • 别名：
    3 oxoacyl [acyl carrier protein] reductase antibody; 3-oxoacyl-[acyl-carrier-protein] reductase antibody; Carbonic reductase 4 antibody; Carbonyl reductase 4 antibody; Carbonyl reductase family member 4 antibody; CBR 4 antibody; Cbr4 antibody; CBR4_HUMAN antibody; FLJ14431 antibody; Quinone reductase CBR4 antibody; SDR45C1 antibody; Short chain dehydrogenase/reductase family 45C member 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Carbonyl reductase family member 4 protein (1-237AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro).
  • 基因功能参考文献：
    1. CBR4 is a mitochondrial NADPH-dependent reductase for o- and p-quinones. PMID: 19000905
    2. Hs17beta-HSD8 and HsCBR4 show a strong genetic interaction in vivo in yeast, where, only if they are expressed together, they rescue the respiratory deficiency and restore the lipoic acid content of oar1Delta cells. PMID: 19571038
  • 亚细胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 组织特异性：
    Detected in liver and kidney (at protein level). Displays the highest expression in neuronal and muscle tissues.
  • 数据库链接：

    HGNC: 25891

    KEGG: hsa:84869

    STRING: 9606.ENSP00000303525

    UniGene: Hs.659311