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CBLL1 Antibody

  • 货号：
    CSB-PA004581GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q75N03
  • 基因名：
    CBLL1
  • 别名：
    c-Cbl-like protein 1 antibody; CasBrM (murine) ecotropic retroviral transforming sequencelike 1 antibody; Casitas B-lineage lymphoma transforming sequence-like protein 1 antibody; Casitas B-lineage lymphoma-like 1 antibody; Casitas B-lineage lymphoma-transforming sequence-like protein 1 antibody; cbll1 antibody; E3 ubiquitin-protein ligase Hakai antibody; Ecadherin binding protein E7 antibody; FLJ23109 antibody; HAKAI antibody; HAKAI_HUMAN antibody; MGC163401 antibody; MGC163403 antibody; OTTHUMP00000206720 antibody; OTTHUMP00000206722 antibody; OTTHUMP00000206724 antibody; RING finger protein 188 antibody; RNF188 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CBLL1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC,IF
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1. Targets CDH1 for endocytosis and degradation. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing. Its function in the WMM complex is unknown.
  • 基因功能参考文献：
    1. The present study demonstrated for the first time that knockdown of Hakai inhibited the proliferation, migration and invasion of nonsmallcell lung cancer cells, and sensitized nonsmallcell lung cancer cells to cisplatin. PMID: 29786107
    2. findings suggest that the E3 ubiquitin-ligase, such as Hakai, may be a better target than proteasome for using novel specific inhibitors in tumor subtypes that follow EMT. PMID: 28675930
    3. These results suggest that stabilization of delta-catenin by Hakai is dependent on Src. PMID: 28069439
    4. these observations suggest that the dimeric architecture of the HYB domain is essential for the phosphotyrosine-binding property of Hakai. PMID: 25074933
    5. By lowering Hakai abundance, miR-203 also reduces Hakai-regulated-cell division. PMID: 23285092
    6. Hakai dimerization allows the formation of a phosphotyrosine-binding pocket that recognizes specific phosphorylated tyrosines and flanking acidic amino acids of Src substrates, such as E-cadherin, cortactin and DOK1. PMID: 22252131
    7. Hakai mediates E-cadherin ubiquitination and degradation triggered by Slit-Robo signaling during colorectal epithelial cell carcinogenesis. PMID: 21283129
    8. Together, these data do not support a requirement for CBLL1 during flavivirus entry and rather suggest an essential role of the ubiquitin/proteasome pathway for flavivirus genome amplification. PMID: 21191016
    9. Results suggest that Hakai is a novel corepressor of ERalpha and may play a negative role in the development and progression of breast cancers. PMID: 20608937
    10. Results suggest that Hakai is an important regulator of cell proliferation and that Hakai may be an oncoprotein and a potential molecular target for cancer treatment. PMID: 19535458

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  • 亚细胞定位：
    Nucleus speckle. Nucleus, nucleoplasm. Cytoplasm.
  • 数据库链接：

    HGNC: 21225

    OMIM: 606872

    KEGG: hsa:79872

    STRING: 9606.ENSP00000401277

    UniGene: Hs.592271