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CASQ2 Antibody

  • 货号：
    CSB-PA004557GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O14958
  • 基因名：
    CASQ2
  • 别名：
    AA033488 antibody; AW146219 antibody; Calsequestrin 2 (cardiac muscle) antibody; Calsequestrin 2 fast twitch cardiac muscle antibody; Calsequestrin antibody; Calsequestrin cardiac muscle isoform antibody; Calsequestrin fast twitch cardiac muscle antibody; Calsequestrin-2 antibody; Calsequestrin2 antibody; cardCSQ antibody; Cardiac calsequestrin 2 antibody; cardiac muscle isoform antibody; CASQ 2 antibody; CASQ2 antibody; CASQ2_HUMAN antibody; cCSQ antibody; ESTM52 antibody; FLJ26321 antibody; FLJ93514 antibody; PDIB2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CASQ2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats.
  • 基因功能参考文献：
    1. We show for the first time a heterozygous CASQ2 variant causing autosomal dominant CPVT in a large family with a severe phenotype. PMID: 27157848
    2. a direct interaction exists between RyR2 and CSQ2, is reported. PMID: 27609834
    3. induced Pluripotent Stem Cell-derived cardiomyocytes are useful for investigating the similarities/differences in the pathophysiological consequences of RyR2 versus CASQ2 mutations underlying Catecholaminergic polymorphic ventricular tachycardia. PMID: 26153920
    4. Mutations in the MYBPC3 and CASQ2 genes and six combinations between loci in the MYBPC3, MYH7 and CASQ2 genes were responsible for cardiomyopathy risk in a studied cohort. PMID: 25892673
    5. We observed association between a CASQ2 polymorphism and SCA due to VA in patients with CAD adjusting for CHF and independent associations between CASQ2 SNPs and CHF adjusting for SCA. PMID: 24444446
    6. Molecular analysis of the CASQ2 gene in 43 probands with Catecholaminergic polymorphic ventricular tachycardia were performed and eight mutations in five patients, were identified. PMID: 21618644
    7. Genetic background of catecholaminergic polymorphic ventricular tachycardia in Japan. PMID: 23595086
    8. In a consanguineous family, a novel homozygous CASQ2 mutation (p.L77P) was identified in a child with CPVT who required implantation of a cardioverter defibrillator due to episodes of syncope while on medical therapy PMID: 22650415
    9. A review of the physiology of Casq2 in cardiac Ca2+ handling and discuss pathophysiological mechanisms that lead to catecholaminergic polymorphic ventricular tachycardia caused by CASQ2 mutations. PMID: 22421959
    10. patients with CASQ2-associated CPVT should be recommended to receive ICDs to prevent sudden death when medical therapy is not effective. PMID: 22481011
    11. Aspartate to histidine casq2 mutation causes arrhythmia in cardiomyocytes generated from catecholaminergic polymorphic ventricular tachycardia patients. PMID: 22050625
    12. Ca(2+) and JNT-dependent disassembly of the CSQ2 polymer PMID: 22123818
    13. Two causative genes of CPVT have been identified: RYR2, encoding the cardiac ryanodine receptor (RyR2) Ca(2+) release channel, and CASQ2, encoding cardiac calsequestrin. Their mutation have been found in 60% of patients with CPVT. PMID: 21872879
    14. Common variations in or near CASQ2, GPD1L, and NOS1AP are associated with increased risk of sudden cardiac death in patients with coronary artery disease PMID: 21685173
    15. Studies identified two phosphorylation sites, Ser(385) and Ser(393 in hCASQ2 by mass-spectroscopy. PMID: 21416293
    16. Catecholaminergic polymorphic ventricular tachycardia (CPTV) mutations modify CASQ2 behaviour, including folding, aggregation/polymerization and selectivity towards Ca2+. PMID: 21265816
    17. up-regulation of casq2 gene in the thyroid of patients with Graves' Hyperthyroidism may lead to the production of autoantibodies and sensitized T-lymphocytes, which cross-react with calsequestrin of patients who develop ophthalmopathy. PMID: 20039900
    18. A regulatory role of CASQ2 on cytosolic Ca(2+) and hERG channels which may contribute to the etiology of CPVT. PMID: 21063088
    19. The human CASQ2 mutation K206N is associated with hyperglycosylation and altered cellular calcium handling. PMID: 20302875
    20. missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel PMID: 11704930
    21. calsequestrin 2 mutations causes severe forms of catecholaminergic polymorphic ventricular tachycardia PMID: 12386154
    22. missense mutation in the CASQ2 gene is associated with autosomal-recessive CPVT(catecholamine-induced polymorphic ventricular tachycardia). PMID: 12732448
    23. A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel. PMID: 12858557
    24. Intracellular Ca2+ cycling in normal heart relies on intricate interplay of CASQ2 with proteins of RyR2 channel complex, and disruption of these interactions can lead to cardiac arrhythmia. PMID: 16601229
    25. CASQ2 mutations identified in polymorphic ventricular tachycardia create distinct abnormalities that lead to abnormal intracellular calcium regulation, thus facilitating the development of tachyarrhythmias. PMID: 16908766
    26. CSQ was a highly phosphorylated protein with a glycan structure predictive of ER-retained proteins. PMID: 17045261
    27. A variant was identified in CASQ2. PMID: 17655857
    28. Data show that all three CPVT-related missense mutations lead to significant reduction in Ca2+-binding capacity and scattering experiments confirm that the linear polymerization behavior of CSQ is linked directly to its high-capacity Ca2+ binding. PMID: 17881003
    29. analysis of how human and rat CASQ2 ventricular tachycardia-related mutations R33Q and L167H alter calcium sensitivity PMID: 18399795
    30. study concludes CASQ2 in the sarcoplasmic reticulum (SR )determines magnitude & duration of Ca release from each SR terminal; 2 CPVT-inducing CASQ2 mutations lead to increased diastolic SR Ca release events and exhibit a similar CPVT disease phenotype PMID: 18469084
    31. A novel mutation of F189L in the CASQ2 gene was identified in families with catecholaminergic polymorphic ventricular tachycardia. PMID: 18543230
    32. REVIEW of Casq2 mutations that cause catecholaminergic polymorphic ventricular tachycardia and their effects on Casq2 function and Ca handling PMID: 18669926
    33. Facilitated maturation of Ca2+ handling properties of human embryonic stem cell-derived cardiomyocytes by calsequestrin expression. PMID: 19357236
    34. Data suggest that calsequestrin (CSQ)2 facilitates Ca(2+) release through RyR2 during systole, while CSQ1 curtails RyR1 opening to maintain Ca(2+) and allow repeated release/ graded activation with increased stimulation frequency. PMID: 19376574
    35. Cardiac and fatal or near-fatal events were not rare in both catecholaminergic polymorphic ventricular tachycardia RYR2 and a CASQ2 mutation probands and affected family members during the long-term follow-up PMID: 19398665

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  • 相关疾病：
    Ventricular tachycardia, catecholaminergic polymorphic, 2 (CPVT2)
  • 亚细胞定位：
    Sarcoplasmic reticulum lumen.
  • 蛋白家族：
    Calsequestrin family
  • 数据库链接：

    HGNC: 1513

    OMIM: 114251

    KEGG: hsa:845

    STRING: 9606.ENSP00000261448

    UniGene: Hs.57975