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CASP12 Antibody

  • 货号：
    CSB-PA001229
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEc cells using Caspase12 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q6UXS9
  • 基因名：
  • 别名：
    CASP 12 antibody; CASP-12 antibody; Casp12 antibody; CASP12P1 antibody; caspase 12 (gene/pseudogene) antibody; caspase 12 pseudogene 1 antibody; CASPC_HUMAN antibody; Inactive caspase-12 antibody; OTTHUMP00000207032 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Caspase12.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
  • 基因功能参考文献：
    1. Piezo1 plays an important role in the apoptosis of human osteoarthritis-derived chondrocytes through a caspase-12-dependent pathway. PMID: 28731145
    2. study indicated the potential effect of Casp12 was on the activation of NF-kappaB by the degradation of IkappaBalpha in NPC cells. PMID: 28380444
    3. CASP12 genotype thus does not influence the phenotype of systemic lupus erythematosus in African-Americans PMID: 26973091
    4. Endoplasmic reticulum stress may be associated with apoptosis of LECs, resulting in cataract formation in diabetic patients. PMID: 27130368
    5. Endoplasmic reticulum stress related factor ATF6 and caspase-12 trigger apoptosis in neonatal hypoxic-ischemic encephalopathy. PMID: 26261584
    6. Expression of caspase-12 was linked to decreased systemic and adipose tissue inflammation in a cohort of African American obese children. PMID: 26582949
    7. We found that RNA interference-induced Caspase-12 silencing increased NOD1, hBD1 and hBD2 expression PMID: 25503380
    8. conclude that the functional CASP12L allele is not a marker for susceptibility and/or severity of CAP PMID: 24586588
    9. EtOH-induced activation of caspase-12 could be one of the underlying mechanisms of hepatocyte apoptosis. PMID: 24224909
    10. Distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). There was no difference in the overall distribution of genotypes within AA with RA, but homozygous patients had lower baseline joint-narrowing scores. PMID: 24515649
    11. CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection. PMID: 21706251
    12. examines the role that CASP12 plays in down-regulating inflammation, we hypothesize that pathogens which exploit the inflammatory response are restrained by an active CASP12 gene product PMID: 21872999
    13. caspase 12 has acquired deleterious mutations PMID: 12054529
    14. Pathways involving this enzyme are involved in a neurodegenerative disease in vivo, and thus offer novel potential targets for the treatment of prion disorders. PMID: 14532116
    15. Na/Ca exchanger overexpression activates caspase-12 PMID: 15033764
    16. Csp12-L attenuates the inflammatory and innate immune response to endotoxins and in doing so may constitute a risk factor for developing sepsis PMID: 15129283
    17. Observational study of genotype prevalence. (HuGE Navigator) PMID: 16917906
    18. The activation of caspase-9 and depolarization of mitochondrial membrane potential were induced by BIK, which were decreased concomitant with caspase-12 silenced. PMID: 17574210
    19. proteolytic activity of caspase-12 is confined to its own proenzyme PMID: 18332441
    20. hRPE cells express a high level of caspase-12S. The regulated expression of caspase-12S suggests that this caspase recruitment domain (CARD)-only protein may be an endogenous dominant negative regulator that modulates inflammatory responses in hRPE cells. PMID: 18791174
    21. estrogen-mediated inhibition of Csp-12L expression is a built-in mechanism that has evolved to protect females from Listeria monocytogenes infection. PMID: 19447924
    22. the NOD2/RIP2 pathway has a role in recognition of Yersinia, but caspase-12 does not modulate innate host defense against Y. pestis PMID: 19721713
    23. The calcium-calpain-caspase-12-caspase-3 cascade is altered in F508del-CFTR expressing cells. PMID: 20041182
    24. Reactive oxygen species promote caspase-12 expression and tubular apoptosis in diabetic nephropathy. PMID: 20299359
    25. Observational study of gene-disease association. (HuGE Navigator) PMID: 20299368
    26. Observational study of gene-disease association. (HuGE Navigator) PMID: 20423816
    27. Observational study of gene-disease association. (HuGE Navigator) PMID: 20577092
    28. Constitutively active forms of caspase-12 (rev-Deltapro1 and rev-Deltapro2) could induce cell death in cells transfected with the corresponding expression vectors. PMID: 20646990

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  • 蛋白家族：
    Peptidase C14A family
  • 组织特异性：
    Detected in heart, kidney, liver, lung, pancreas, small intestine, spleen, stomach, thymus and testis.
  • 数据库链接：

    HGNC: 19004

    OMIM: 608633

    KEGG: hsa:100506742

    STRING: 9606.ENSP00000424038

    UniGene: Hs.476989