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CARD18 Antibody

  • 货号：
    CSB-PA004521LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA004521LA01HU diluted at 1:100 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CARD18 Polyclonal antibody
  • Uniprot No.：
    P57730
  • 基因名：
  • 别名：
    CARD18 antibody; ICEBERG antibody; UNQ5804/PRO19611Caspase recruitment domain-containing protein 18 antibody; Caspase-1 inhibitor Iceberg antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Caspase recruitment domain-containing protein 18 protein (1-90AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CARD18 Antibody (CSB-PA004521LA01HU)，的标记方式是Non-conjugated。对于CARD18 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004521LB01HU CARD18 Antibody, HRP conjugated ELISA
    FITC CSB-PA004521LC01HU CARD18 Antibody, FITC conjugated
    Biotin CSB-PA004521LD01HU CARD18 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
  • 基因功能参考文献：
    1. In lesional epidermis of patients with lichen planus, CARD18 expression was either greatly diminished or entirely absent whereas in non-lesional areas expression was comparable to normal skin. PMID: 28506683
    2. CARD18 expression differs in healthy and psoriatic skin; moreover, CARD18 demonstrated altered response under inflammatory conditions in healthy and psoriatic skin PMID: 27023378
    3. CARD18 may be both a promising marker for prognosis and a target protein for treatment of gastric cancer. PMID: 23948415
  • 组织特异性：
    Primarily expressed in the heart and placenta.
  • 数据库链接：

    HGNC: 28861

    OMIM: 605354

    KEGG: hsa:59082

    STRING: 9606.ENSP00000436691

    UniGene: Hs.56279