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CARD11 Antibody

  • 货号：
    CSB-PA866306ESR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: CARD11 antibody at 4µg/ml + K562 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 133 kDa
      Observed band size: 133 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CARD11 Polyclonal antibody
  • Uniprot No.：
    Q9BXL7
  • 基因名：
  • 别名：
    0610008L17Rik antibody; 2410011D02Rik antibody; Bcl10 interacting maguk protein 3 antibody; BIMP 3 antibody; BIMP3 antibody; CAR11_HUMAN antibody; CARD 11 antibody; CARD containing MAGUK protein 3 antibody; Card maguk protein 1 antibody; CARD-containing MAGUK protein 1 antibody; CARD11 antibody; CARD11 protein antibody; Carma 1 antibody; CARMA1 antibody; Caspase recruitment domain containing protein 11 antibody; Caspase recruitment domain family member 11 antibody; Caspase recruitment domain-containing protein 11 antibody; MGC133069 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Caspase recruitment domain-containing protein 11 protein (985-1154AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Adapter protein that plays a key role in adaptive immune response by transducing the activation of NF-kappa-B downstream of T-cell receptor (TCR) and B-cell receptor (BCR) engagement. Transduces signals downstream TCR or BCR activation via the formation of a multiprotein complex together with BCL10 and MALT1 that induces NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways. Upon activation in response to TCR or BCR triggering, CARD11 homooligomerizes to form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10 and subsequent recruitment of MALT1: this leads to I-kappa-B kinase (IKK) phosphorylation and degradation, and release of NF-kappa-B proteins for nuclear translocation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Promotes linear ubiquitination of BCL10 by promoting the targeting of BCL10 to RNF31/HOIP. Stimulates the phosphorylation of BCL10. Also activates the TORC1 signaling pathway.
  • 基因功能参考文献：
    1. CARMA1 forms CARMA1-BCL10-MALT1-TRAF6 signalosome.CARMA1, the BCL10 nucleator, serves as a hub for formation of star-shaped filamentous networks of BCL10 and significantly decreases the lag period of BCL10 polymerization. PMID: 29382759
    2. study results suggest variations in the inflammasome, particularly in NLRP1 and CARD11, may be associated with chronic Chagas cardiomyopathy PMID: 29438387
    3. CARD11, a scaffold protein required for B-cell receptor (BCR)-induced NF-kappaB activation, was screened in an additional 173 MCL samples and mutations were observed in 5.5% of cases. PMID: 27224912
    4. CARMA1 may be aberrantly upregulated in T-ALL, leading to disease progression and migration of leukemic cells to the CNS PMID: 27698445
    5. findings indicate that a single hypomorphic mutation in CARD11 can cause potentially correctable cellular defects that lead to atopic dermatitis PMID: 28628108
    6. NF-kappaB and beta-catenin signaling by gain-of-function mutations in CARMA1 augments WNT stimulation and is required for regulating the expression of distinct NF-kappaB target genes to trigger cell-intrinsic and extrinsic processes that promote DLBCL lymphomagenesis PMID: 26776161
    7. CARD11 mutations are rare in patients with CD5+ DLBCL. PMID: 27915469
    8. results define molecular determinants that control the production of Lin(Ub)n-Bcl10, an important signaling intermediate in TCR and oncogenic CARD11 signaling. PMID: 27777308
    9. We evaluated the relationship between rs4722404 polymorphism in the CARD11 gene, and the risk and clinical features of psoriasis vulgaris in a southern Chinese Han cohort.We identified no association between the SNP and risk of psoriasis vulgaris. PMID: 27421022
    10. single amino acid oncogenic CARD11 mutations can perturb or bypass the action of redundant inhibitory REs to achieve the level of hyperactive CARD11 signaling required to support lymphoma growth. PMID: 26884334
    11. Cooperative Control of Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling by an Unusual Array of Redundant Repressive Elements. PMID: 26884335
    12. CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. PMID: 26747248
    13. Data show that caspase recruitment domain-containing protein 11/B-cell CLL/lymphoma 10/mucosa-associated lymphoid tissue lymphoma translocation gene 1 signaling drives lymphoproliferation through NF-kappa B and c-Jun N-terminal kinase activation. PMID: 26668357
    14. CARD11-mediated alterations in NF-kappaB signaling may be an early event in the development of cutaneous squamous cell carcinoma PMID: 26212909
    15. Taken together, our data indicate that miR-539 is a novel regulator of migration and invasion in human thyroid cancer cells by targeting CARMA1. PMID: 26206083
    16. CARMA1 clustering through SH3-GUK domain interactions is required for its activation of NF-kappaB signalling PMID: 25602919
    17. Both carried homozygous germline mutations in CARD11 (p.Cys150*), impairing NF-kappaB signaling and IL-2 production PMID: 26289640
    18. Three patients have been described with mild B-cell lymphocytosis and a CARD11 C49Y missense mutation. PMID: 25930198
    19. Overexpression of CARMA-BCL10-MALT in T-ALL may contribute to the constitutive cleavage and inactivation of A20, which enhances NF-kappaB signaling and may be related to T-ALL pathogenesis. PMID: 25384343
    20. Data indicate that caspase recruitment domain family, member 11 protein CARD11 has complex 5'UTRs and is sensitive to eIF4A RNA helicase inhibition. PMID: 25320244
    21. Data indicate that caspase recruitment domain membrane-associated guanylate kinase protein 1 (CARMA1)-silenced cells K562/shCARMA 1-93 showed the greatest inhibition of CARMA 1 gene and protein expressions. PMID: 25001930
    22. CKIP-1 interacts with CARMA1 and has an inhibitory effect on PKCtheta;-CBM-NF-kappaB signaling. PMID: 24465689
    23. Data indicate that phosphorylation of Carma1 down-stream of TCR/CD28-dependent NF-kappaB induction is regulated in part by Akt. PMID: 24548923
    24. CARMA1 CARD was then purified to homogeneity and crystallized at 293 K. Finally, X-ray diffraction data were collected to a resolution of 3.2 A from a crystal belonging to space group P2(1)2(1)2(1) PMID: 23545653
    25. Combining crystallography, nuclear magnetic resonance, and electron microscopy, we reveal the structure of the Bcl10 CARD filament and the mode of interaction between CARMA1 and Bcl10 PMID: 24074955
    26. SMO activates trimeric G proteins and CARMA1-associated signaling complex, leading to NF-kappaB activation and results in diffuse large B-cell lymphoma. PMID: 23632891
    27. distinct CARMA1-dependent control of key cell cycle proteins in T cells is coordinated by ADAP PMID: 22411628
    28. In patients with CARD11 deficiency, the combination of impaired activation and especially upregulation of inducible T-cell costimulator on T cells. PMID: 23374270
    29. These data provide the first evidence that ubiquitination of CARMA1 by STUB1 promotes TCR-induced NF-kappaB signaling. PMID: 23322406
    30. CARD11 gain-of-function mutations selectively confer the ability to associate with Bcl10 and induce K63-linked ubiquitination of Bcl10. PMID: 23149938
    31. The incidence of CARD11 mutations was 10.7% in Middle Eastern diffuse large B-cell lymphoma. PMID: 22397314
    32. Findings show that regulation of CARD11 signaling is a critical switch governing the decision between death and proliferation in antigen-stimulated mature B cells. PMID: 23027925
    33. CARD11 mutations may predispose to B but not T lymphoid malignancy. PMID: 23129749
    34. The present study failed to find any mut-ation in MYD88, CARD11 or CD79B in ocular MALT lymphoma. PMID: 22808296
    35. PKCdelta is a negative regulator in T cell activation through inhibiting the assembly of CARMA1 signalosome. PMID: 22528498
    36. TLR-dependent TRAF6-MKK3-p38 MAPK signaling pathway synergizes with PKCtheta;-MEK-ERK signaling pathway. CARMA1 plays a crucial role in mediating this synergistic effect via TRAF6. PMID: 22303480
    37. In Jurkat cells, CARMA1 is required for induction of Th2 transcription factors, GATA3 and JunB, and controls IL-4, IL-5, and IL-10 production. PMID: 22371397
    38. expression of CARMA1 mRNA is likely associated with the expression of MUM1 and shows male predominance in diffuse large B cell lymphoma. PMID: 21569705
    39. A combination of in vitro and in vivo studies demonstrates that the CARMA1 transgene is required for optimal T cell responses to T cell receptor engagement and development of allergic airway inflammation, after activation of T cells in a murine model. PMID: 22075698
    40. genetic polymorphism is associated with common variable immunodeficiency PMID: 21905497
    41. Very low mutation frequency of exons 5-9 in the CARD11 gene from 186 adult acute leukemia and 31 multiple myeloma samples. PMID: 21176849
    42. PP2A-mediated dephosphorylation of Carma1 is a critical step to limit T-cell activation and effector cytokine production. PMID: 21157432
    43. CARM1 is transcriptional coactivators that deposit H3R17me2a and H4R3me2a marks, respectively. PMID: 21172665
    44. results establish a mechanism that explains how diffuse large B cell lymphoma-associated mutations in CARD11 can initiate spontaneous, receptor-independent activation of NF-kappaB PMID: 20799731
    45. The mutations of the oncogene CARD11 may contribute to NF-kappaB activation and thereby play a role in the pathogenesis of Primary CNS lymphoma. PMID: 20544211
    46. the ADAP CARMA1 binding site is required for IKK gamma ubiquitination; both TAK1 and CARMA1 binding sites are required for IkappaB alpha phosphorylation and degradation and NF-kappaB nuclear translocation PMID: 20164171
    47. CARMA1 is an essential signaling component that mediates TCR-induced NF-kappa B activation. PMID: 12154356
    48. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation and CD28 costimulation-dependent Jnk activation. PMID: 12154360
    49. CARMA1 and CARMA3 bind to Ikappa kinase gamma-NFkappaB in B and T lymphocytes PMID: 15184390
    50. Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. PMID: 16356856

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  • 相关疾病：
    B-cell expansion with NFKB and T-cell anergy (BENTA); Immunodeficiency 11 A (IMD11A); Immunodeficiency 11B with atopic dermatitis (IMD11B)
  • 亚细胞定位：
    Cytoplasm. Membrane raft.
  • 组织特异性：
    Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K-562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in H
  • 数据库链接：

    HGNC: 16393

    OMIM: 607210

    KEGG: hsa:84433

    STRING: 9606.ENSP00000380150

    UniGene: Hs.648101