Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. CARD10 Antibody

CARD10 Antibody

  • 货号：
    CSB-PA001213
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 293 cells using CARD 10 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    Q9BWT7
  • 基因名：
  • 别名：
    Bcl10 binding protein and activator of NFKB antibody; BIMP1 antibody; CAR10_HUMAN antibody; CARD 10 antibody; CARD containing MAGUK 3 protein antibody; CARD-containing MAGUK 3 antibody; CARD-containing MAGUK protein 3 antibody; CARD10 antibody; Carma 3 antibody; CARMA3 antibody; Caspase Recruitment Domain family member 10 antibody; Caspase recruitment domain-containing protein 10 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human CARD 10.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Activates NF-kappa-B via BCL10 and IKK.
  • 基因功能参考文献：
    1. The results suggest that the involvement of CARMA3 in DNA damage-induced NF-kappaB is through the recruitment of TRAF6. PMID: 28717989
    2. Card10 polymorphisms may not be linked with psoriasis vulgaris in the southern Han Chinese population. PMID: 28301668
    3. Data indicate no association between caspase recruitment domain family, member 10 protein (CARD10) polymorphism rs6000782 and type 1 autoimmune hepatitis (AIH) in a Japanese population. PMID: 26652023
    4. Findings indicate that CARMA3 may suppress the activation of the P38 MAPK signaling pathway to regulate invasion, migration and apoptosis of lung cancer cells by activating NF-small ka, CyrillicB (P65) in the nucleus. PMID: 26526492
    5. miR-24 inhibited cell proliferation, invasion and epithelial to mesenchymal transition in bladder cancer cells by downregulation of CARMA3 PMID: 26252200
    6. The study identified the DEP domain-containing protein DEPDC7 as cellular binding partner of CARMA2 and CARMA3 proteins. PMID: 25541973
    7. A novel mechanism of CARMA3 in lung cancer stemness and metastasis through the negative regulation of NME2 was identified. PMID: 25906011
    8. CARMA3 regulates the ovarian cancer cell proliferation, cell cycle progression, and chemoresistance. PMID: 24833094
    9. CARMA3 is overexpressed in pancreatic cancer and regulates malignant cell growth, invasion, and NF-kappaB signaling, which was dependent on its association with Bcl10. PMID: 24633921
    10. CARMA3 is overexpressed in bladder cancer and regulates malignant cell growth and NF-kappaB signaling. PMID: 24443255
    11. Genetic variation within PARP1 and CARD10 was associated with rate of hippocampal neurodegeneration in APOE e3/e3 patients. PMID: 23608917
    12. CARD10 may be involved in hepatic carcinogenesis associated with hepatitis C in Egyptian patients. PMID: 24018495
    13. overexpression of CARMA3 in human glioma and its correlation with tumor grade. PMID: 23893382
    14. Data show that CARMA3 may serve as a novel and prognostic marker for renal cell carcinoma (RCC) and play a role during the development and progression of the disease. PMID: 23771851
    15. CARMA3 facilitates proliferation and inhibits apoptosis through nuclear factor-kappaB signaling. PMID: 23708960
    16. this study found that CARMA3 is overexpressed in colon cancers and contributes to malignant cell growth by facilitating cell cycle progression through NF-kappaB mediated upregulation of cyclin D1. PMID: 22884800
    17. The overexpression of CARMA3 was significantly correlated with TNM stage (P = 0.022) and tumor status (P = 0.013). PMID: 22615840
    18. Polymorphisms of ATOH7, TGFBR3 and CARD10 influence the size of optic disc area. PMID: 21307088
    19. Data show that CARMA3 and Bcl10 contributed to several characteristics of EGFR-associated malignancy, including proliferation, survival, migration, and invasion. PMID: 21406399
    20. CARMA1 and CARMA3 bind to Ikappa kinase gamma-NFkappaB in B and T lymphocytes PMID: 15184390
    21. Protein kinase C-CARMA3 signaling axis plays an essential role in lysophosphatidic acid-induced ovarian cancer cell in vitro invasion. PMID: 17724468
    22. results further define the molecular mechanisms that control activation of NF-kappaB and reveal a function for A20 in the regulation of CARMA and BCL10 activity in lymphoid and non-lymphoid cells PMID: 18349075
    23. Data demonstrate that lysophosphatidic acid stimulates thymic stromal lymphopoietin and CCL20 expression in bronchial epithelial cells via CARMA3-mediated NF-kappaB activation. PMID: 18757306

    显示更多

    收起更多

  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Detected in adult heart, kidney and liver; lower levels in intestine, placenta, muscle and lung. Also found in fetal lung, liver and kidney.
  • 数据库链接：

    HGNC: 16422

    OMIM: 607209

    KEGG: hsa:29775

    STRING: 9606.ENSP00000251973

    UniGene: Hs.57973