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CAPZA1 Antibody

  • 货号：
    CSB-PA928245
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA928245(CAPZA1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA928245(CAPZA1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P52907
  • 基因名：
  • 别名：
    Cap Z antibody; Cappa 1 antibody; Cappa1 antibody; Capping protein (actin filament) muscle Z line alpha 1 antibody; Capping protein alpha 1 antibody; Capping protein muscle Z line alpha 1 antibody; CapZ alpha 1 antibody; CapZ alpha-1 antibody; CAPZ antibody; CAPZA 1 antibody; Capza1 antibody; CAZ 1 antibody; CAZ1 antibody; CAZA1_HUMAN antibody; F actin capping protein alpha 1 subunit antibody; F-actin-capping protein subunit alpha-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human CAPZA1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.
  • 基因功能参考文献：
    1. Data show that CAPZA1 inhibits EMT in hepatocellular carcinoma (HCC cells by regulating actin cytoskeleton remodeling, thereby reducing the metastatic ability of the cells. PMID: 28093067
    2. Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ alpha-1) and profilin 2. PMID: 26764407
    3. mDia1 displaced from the barbed end by CapZ Actin Capping Protein can randomly slide along the actin filament and later return. PMID: 26566078
    4. The present study suggests that CAPZA1 could be a marker of good prognosis in gastric cancer and shows that CAPZA1 is associated with decreased cancer cell migration and invasion. PMID: 23545944
    5. CAPAZA1 is over expressed in malignant melanoma. PMID: 21566537
    6. V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein PMID: 12488317
    7. Cd2 antigen is linked to this protein via CMS and CIN85. PMID: 12690097
    8. CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein PMID: 16987810
    9. Damaging exercise induced the expression of capZalpha, MCIP1, CARP1, DNAJB2, c-myc, and junD, each of which are likely involved in skeletal muscle growth, remodeling, and stress management. PMID: 18321953

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton.
  • 蛋白家族：
    F-actin-capping protein alpha subunit family
  • 数据库链接：

    HGNC: 1488

    OMIM: 601580

    KEGG: hsa:829

    STRING: 9606.ENSP00000263168

    UniGene: Hs.744974