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CAMLG Antibody

  • 货号：
    CSB-PA004475LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate, HEK293 whole cell lysate, U87 whole cell lysate, SH-SY5Y whole cell lysate
      All lanes: CAMLG antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 33 kDa
      Observed band size: 33 kDa
    • Immunofluorescent analysis of HepG2 cells using CSB-PA004475LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
    • Immunoprecipitating CAMLG in HEK293 whole cell lysate
      Lane 1: Rabbit control IgG (1µg) instead of CSB-PA004475LA01HU in HEK293 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
      Lane 2: CSB-PA004475LA01HU (8µg) + HEK293 whole cell lysate (500µg)
      Lane 3: HEK293 whole cell lysate (10µg)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CAMLG Polyclonal antibody
  • Uniprot No.：
    P49069
  • 基因名：
    CAMLG
  • 别名：
    CAMLG antibody; CAML antibody; Calcium signal-modulating cyclophilin ligand antibody; CAML antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Calcium signal-modulating cyclophilin ligand protein (1-189AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CAMLG Antibody (CSB-PA004475LA01HU)，的标记方式是Non-conjugated。对于CAMLG Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004475LB01HU CAMLG Antibody, HRP conjugated ELISA
    FITC CSB-PA004475LC01HU CAMLG Antibody, FITC conjugated
    Biotin CSB-PA004475LD01HU CAMLG Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IF, IP
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IF 1:50-1:500
    IP 1:200-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells.
  • 基因功能参考文献：
    1. Found that the calcium-modulating cyclophilin ligand (CAMLG), which is involved in Ca(2+) signaling, was the major host cell PilA binding protein. PMID: 23266901
    2. Results indicate calcium-modulating cyclophilin ligand (CAML) and WRB as components of the TRC40 receptor complex and a crucial mechanism for driving ER membrane insertion of TA proteins in mammalian cells. PMID: 23041287
    3. CAML was found to play a crucial role in the PRL/PRLR-dependent growth of breast cancer cells. PMID: 21128111
    4. this study demonstrated that DENV manipulated the levels of CAML to subvert the apoptotic process which in turn favoured efficient virus production. PMID: 22281498
    5. CAMLG was more frequently significantly overexpressed in acute myeloid leukemia patients with CD56 immunophenoytpe PMID: 12031912
    6. Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets cellular CAML to increase the cytosolic Ca(2+) response, which consequently protects cells from mitochondrial damage and apoptosis PMID: 12388711
    7. CAML is an important signal transducer for the actions of Ang II in regulating the calcineurin-NFAT pathway and the interaction of CAML with ATRAP may mediate the Ang II actions in vascular physiology PMID: 15668245
    8. The intracellular C-terminus of fibrocystin interacts with CAML, a protein with an intracellular distribution that is similar to that of PKD2. PMID: 16243292
    9. Binding of the MUC1 CT to CAML in human epithelial cells was confirmed by reciprocal coimmunoprecipitations, confocal microscopy, protein crosslinking, and coupled transcription/translation analyses. PMID: 19135167

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 组织特异性：
    Ubiquitous. Highest levels in brain, testis and ovary.
  • 数据库链接：

    HGNC: 1471

    OMIM: 601118

    KEGG: hsa:819

    STRING: 9606.ENSP00000297156

    UniGene: Hs.529846