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CAMK2N1 Antibody

  • 货号：
    CSB-PA004469NA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunofluorescence staining of HepG2 cells with CSB-PA004469NA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CAMK2N1 Polyclonal antibody
  • Uniprot No.：
    Q7Z7J9
  • 基因名：
    CAMK2N1
  • 别名：
    CAMK2N1Calcium/calmodulin-dependent protein kinase II inhibitor 1 antibody; CaMKII inhibitory protein alpha antibody; CaMKIIN-alpha antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence from Human Calcium/calmodulin-dependent protein kinase II inhibitor 1 protein (9-27AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CAMK2N1 Antibody (CSB-PA004469NA01HU)，的标记方式是Non-conjugated。对于CAMK2N1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA004469NB01HU CAMK2N1 Antibody, HRP conjugated ELISA
    FITC CSB-PA004469NC01HU CAMK2N1 Antibody, FITC conjugated
    Biotin CSB-PA004469ND01HU CAMK2N1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Potent and specific inhibitor of CaM-kinase II (CAMK2).
  • 基因功能参考文献：
    1. CAMK2N1 expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
    2. Hypermethylation of RUNX3/CAMK2N1 is associated with poor clinical outcome in Type II EOC, also after macroscopic complete resection. PMID: 26175272
    3. contributes to prostate cancer growth and survival through androgen receptor-dependent signaling PMID: 25296973
    4. Analyses suggest that CAMK2N1 plays a tumor suppressive role in prostate cancer cells. Reduced CAMK2N1 expression correlates to human prostate cancer progression and predicts poor clinical outcome. PMID: 25003983
    5. hCaMKIINalpha suppresses tumor growth by inducing cell cycle arrest via p27 stabilization PMID: 18305109

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  • 亚细胞定位：
    Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density.
  • 蛋白家族：
    CAMK2N family
  • 组织特异性：
    Widely expressed. Nor detected in skeletal muscle.
  • 数据库链接：

    HGNC: 24190

    OMIM: 614986

    KEGG: hsa:55450

    UniGene: Hs.731383