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CALN1 Antibody

  • 货号：
    CSB-PA004457GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BXU9
  • 基因名：
    CALN1
  • 别名：
    CaBP8 antibody; CABP8_HUMAN antibody; Calcium binding protein 8 antibody; Calcium binding protein antibody; Calcium binding protein CABP8 antibody; Calcium-binding protein 8 antibody; Caln1 antibody; Calneuron I antibody; Calneuron-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human CALN1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity. May play a role in the physiology of neurons and is potentially important in memory and learning.
  • 基因功能参考文献：
    1. up regulation serum exosomal miR-675 and down regulation of CALN1 in tumor specimen was also found to be associated with the metastatic phenotype in osteosarcoma patients. PMID: 29626470
    2. CALN1 gene encoding calneuron 1 had the strongest correlation with CYP11B2 (aldosterone synthase) among genes encoding Ca2+-binding proteins in Aldosterone-producing Adenoma. PMID: 29109191
    3. this report has further supported for associations of genetic variants in the ITIH4 and CALN1 genes with schizophrenia and provided the first evidence that the variants regulate ITIH4 AND CALN1 expression in the dorsolateral prefrontal cortex PMID: 26991396
    4. detected the first genome-wide significant association of schizophrenia with CALN1, which is a predicted target of MIR137, and thus provide new evidence for the associations between MIR137 targets and schizophrenia PMID: 26206863
    5. The protein is most abundant in Purkinje cells of the cerebellum and principal neurons of the cortex and limbic brain whereas no expression in glial cells is apparent. PMID: 26116628
    6. provide strong evidence that CALN1 is a target of miR-137. PMID: 26163462
    7. CaBP7 and 8 possess a targeting mechanism that is unique amongst the CaBPs that may contribute to differential functional Ca(2+)-sensing by these family members. PMID: 19338761

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  • 亚细胞定位：
    Golgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Cytoplasm, perinuclear region. Cell membrane; Single-pass type IV membrane protein.
  • 组织特异性：
    Brain specific.
  • 数据库链接：

    HGNC: 13248

    OMIM: 607176

    KEGG: hsa:83698

    STRING: 9606.ENSP00000378690

    UniGene: Hs.592750