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  4. CALD1 Antibody

CALD1 Antibody

  • 货号：
    CSB-PA060173
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q05682
  • 基因名：
  • 别名：
    CAD antibody; CALD 1 antibody; CALD1 antibody; CALD1_HUMAN antibody; Caldesmon 1 antibody; Caldesmon 1 Isoform 1 antibody; Caldesmon 1 Isoform 2 antibody; Caldesmon 1 Isoform 3 antibody; Caldesmon 1 Isoform 4 antibody; Caldesmon 1 Isoform 5 antibody; Caldesmon antibody; Caldesmon1 antibody; CDM antibody; H CAD antibody; HCAD antibody; L CAD antibody; LCAD antibody; MGC21352 antibody; NAG22 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from Human Caldesmon around the non-phosphorylation site of S789.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also plays an essential role during cellular mitosis and ...显示更多
  • 基因功能参考文献：
    1. rs 3807337 polymorphism of CALD1 gene is associated with diabetic nephropathy occurrence in type 1 diabetes. PMID: 28255976
    2. ANXA1 and CALD1 proteins are independent markers for tamoxifen therapy outcome and are associated to fast tumor progression. PMID: 26657294
    3. Data indicate that low-molecular-weight caldesmon isoforms (L-CAD) promotes migration and invasiveness of urothelial bladder carcinoma (BC) cells. PMID: 26430961
    4. Caldesmon and smoothelin staining allows better delineation of the muscularis propria from the desmoplastic stromal reaction which provides a critical aide for proper staging of colonic adenocarcinomas. PMID: 24551305
    5. caldesmon is not useful in distinguishing between peritoneal epithelioid mesotheliomas and papillary serous carcinomas involving the peritoneum PMID: 23196794
    6. The data suggest that PKGIbeta enhances breast cancer cell motility and invasive capacity, at least in part, by phosphorylating CaD. PMID: 23418348
    7. Caldesmon is a possible predictor of endometrial dysregulation in patients with endometriosis. PMID: 23575144
    8. Caldesmon expression inhibits cancer cell migration and invasiveness. PMID: 23265641
    9. Disruption of the normal inhibitory function of human caldesmon 1 enhances intestinal peristalsis in both wild-type zebrafish larvae and mutant larvae that lack enteric nerves PMID: 22316291
    10. Data found phasic phosphorylation of caldesmon and ERK 1/2 during contractions in human myometrium. PMID: 21738699
    11. Our results show a differential behavior of h- and l-caldesmon isoforms in epithelium and stroma of colon adenocarcinoma and lymph node metastases. PMID: 21626272
    12. Novel biological cascade that involved the phosphorylation activation of CaD by PFTK1 kinase in promoting formation of actin stress fibers. PMID: 21184254
    13. An involvement of caldesmon in the susceptibility to diabetic nephropathy in type 1 diabetes, independently from environmental glucose levels. PMID: 20801058
    14. h-caldesmon is useful in distinguishing atypical polypoid adenomyoma from myoinvasive endometrioid carcinoma PMID: 21131830
    15. Stretch activates myometrium via ERK, caldesmon and focal adhesion signaling PMID: 19834610
    16. Results describe the mechanisms of PC6 action in decidualization and identify caldesmon as one of its physiological substrates. PMID: 19764806
    17. The effect of a C-terminal fragment of CaD (H32K) on the kinetics of the in vitro actin polymerization by monitoring the fluorescence of pyrene-labeled actin, was studied. PMID: 19889635
    18. Specific but variable expression of h-caldesmon in leiomyosarcomas PMID: 11759055
    19. Motifs of the caldesmon family. PMID: 11996092
    20. results suggest a role for the caldesmon gene in susceptibility to diabetic nephropathy in type 1 diabetes PMID: 15047636
    21. Alternative splicing contributes to dysfunctionality of glioma neovascularization. PMID: 15161654
    22. plays a crucial role in mediating the effects of Ca(2+)-calmodulin on the dynamics of the actin cytoskeleton PMID: 15226374
    23. unphosphorylated, but not ERK-phosphorylated, caldesmon could stabilize actin filaments and resist F-actin severing or depolymerization in both smooth muscle and nonmuscle cells PMID: 15456752
    24. These results suggest that CaD is critically involved in the regulation of the actin cytoskeleton and migration in EC, and that p38 MAPK-mediated CaD phosphorylation may be involved in endothelial cytoskeletal remodeling. PMID: 15521070
    25. Serum l-CaD level as determined by ELISA is a good discriminator between glioma patients versus patients with other intracranial tumor. PMID: 15958622
    26. K-cyclin expression modulates the activity of caldesmon and through this the microfilament functions in cells PMID: 16115893
    27. Phosphorylation of caldesmon by PAK is a dynamic process required to regulate actin dynamics and membrane protrusions in wound-induced cell migration. PMID: 16800003
    28. low molecular weight isoform CaD undergoes a DNA replication-associated switch in localization from the cytoplasm to the nuclei of endothelial cells/endothelial progenitor cells in human tumor vasculature PMID: 17582218
    29. Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation. PMID: 17631293
    30. A subset of the tumor-specific splicing alterations (ACTN1, CALD1, and VCL) was found in all three organs and may represent general cancer-related splicing events. PMID: 18353764
    31. GR directly bound to the two glucocorticoid-response element-like sequences in the human CALD1 promoter and transactivated the CALD1 gene, thereby up-regulating the CaD protein. PMID: 18772142
    32. Vaginal caldesmon expression is significantly decreased in women with anterior vaginal wall prolapse compared to normal subjects PMID: 19582387

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  • 亚细胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, myofibril. Cytoplasm, cytoskeleton, stress fiber.
  • 蛋白家族：
    Caldesmon family
  • 组织特异性：
    High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
  • 数据库链接：

    HGNC: 1441

    OMIM: 114213

    KEGG: hsa:800

    STRING: 9606.ENSP00000354826

    UniGene: Hs.490203