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CALCR Antibody

  • 货号：
    CSB-PA153268
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA153268(CALCR Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    P30988
  • 基因名：
  • 别名：
    CALCR; Calcitonin receptor; CT-R
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Fusion protein of Human CALCR
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:15-1:50
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.; Receptor for calcitonin but is unable to couple to G proteins and activate adenylyl cyclase. Does not undergo receptor internalization following ligand binding.
  • 基因功能参考文献：
    1. CTR activates AKAP2-anchored cAMP-dependent protein kinase A, which then phosphorylates tight junction proteins ZO-1 and claudin 3. PMID: 28428082
    2. structure of a full-length class B receptor, the calcitonin receptor, in complex with peptide ligand and heterotrimeric Galphasbetagamma protein determined by Volta phase-plate single-particle cryo-electron microscopy PMID: 28437792
    3. Data suggest that a single GlcNAc residue at CTR N130 (asparagine 130) is responsible for enhanced affinity of calcitonin for CTR ECD; the same appears to apply for enhanced affinity of amylin for RAMP2-CTR ECD. [GlcNAc = N-acetylglucosamine; CTR = calcitonin receptor; ECD = extracellular domain; RAMP2 = receptor (calcitonin) activity modifying protein 2]. PMID: 28614667
    4. Males with CALCR TT genotype (rs1801197) have 13 fold increased risk for kidney stone disease. No significant association of rs1042138 with kidney stone in West Bengal, India. PMID: 28435134
    5. Calcitonin and Amylin Receptor Peptide Interaction Mechanisms: INSIGHTS INTO PEPTIDE-BINDING MODES AND ALLOSTERIC MODULATION OF THE CALCITONIN RECEPTOR BY RECEPTOR ACTIVITY-MODIFYING PROTEINS. PMID: 26895962
    6. An association between fluorosis and the Alu I polymorphism in the CTR gene was observed in fluoride-exposed populations. PMID: 25402775
    7. The C1377T polymorphism in the CTR gene is associated with bone mineral density at the lumbar spine in a postmenopausal Han Chinese population PMID: 25055932
    8. There was no statistically significant difference in CTR gene nucleotide sequence polymorphisms at 1377-bp between Chinese Xinjiang Han and Uygur patients with primary osteoporosis. PMID: 24522475
    9. Data indicate a potential association between 3'UTR+18C>T and intron 1 polymorphisms in the CALCR and the risk of kidney stone disease. PMID: 24296906
    10. Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias. PMID: 24643196
    11. High calcitonin receptor is associated with prostate cancer. PMID: 23820954
    12. CTR was expressed by glioma cells in a majority of GBM tumours tested. PMID: 22335784
    13. Allele C in CALCR gene was associated with reduced bone mass in cystic fibrosis children. PMID: 21462477
    14. highly expressed on normal T- and B-lymphocytes PMID: 19445988
    15. Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands. PMID: 19903822
    16. relationship between calcitonin receptor (CTR) genotype and buccal marginal bone loss observed at stage II surgery for endosseous implants PMID: 11858573
    17. an important role for filamin in the endocytic sorting and recycling of the internalized CTR PMID: 12531889
    18. Co-expression of calcitonin receptors (CT) lacking a portion of domain 1 with receptor activity-modifying protein (RAMP) 1, 2, or 3 appears to produce functional CT-(8-32)-sensitive adrenomedullin receptors. PMID: 12565884
    19. ALUI calcitonin receptor polymorphism genotype showed a positive association with prevalence of osteoporosis in the subjects PMID: 12771454
    20. analysis of the amino terminus of the calcitonin receptor and its effects on docking constraints PMID: 14583624
    21. the site of attachment of a photoaffinity label was identified as residue Leu(348) within the third extracellular loop of the receptor PMID: 15155765
    22. existence of two novel splice variants of human CTR and splicing patterns could be involved in the post-transcriptional regulation of the gene. PMID: 15563840
    23. Effects of VDR (Fok-I) and CTR gene polymorphism contribute to understanding of pathogenesis of urinary calculi. Potential candidate gene in search for genetic causes of paediatric calcium oxalate nephrolithiasis. PMID: 15856322
    24. normal cell surface expression, mobilization of intracellular calcium, and Erk activation requires the cytoplasmic C-terminal tail of the CTR PMID: 15860547
    25. The calcitonin receptor model is consistent with cooperative interaction between the receptor amino terminus and the receptor core. PMID: 15929987
    26. the MCP-1-induced TRAP(+)/CTR(+) multinuclear cells represent an arrested stage in osteoclast differentiation, after NFATc1 induction and cellular fusion but prior to the development of bone resorption activity PMID: 16280328
    27. up-regulation of CT biosynthesis and activation of CT-CTR axis in primary prostate tumors may have direct relevance in their progression to the metastatic phenotype. PMID: 17487556
    28. Study data suggest that the AluI polymorphism of the CTR gene can be useful as a genetic marker in the interindividual susceptibility of QUS parameters by the interaction with nutritional status as a lifestyle factor. PMID: 17709929
    29. High calcitonin receptor is associated with multiple myeloma PMID: 17714780
    30. BsmI and AluI polymorphisms are not related to the forearm bone values either reflecting mass or geometrical variables in this male population. PMID: 18622089
    31. the juxtamembranous region of the amino terminus of the family B G protein-coupled calcitonin receptor plays a critical role in small-molecule agonist action PMID: 19447889

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 数据库链接：

    HGNC: 1440

    OMIM: 114131

    KEGG: hsa:799

    STRING: 9606.ENSP00000352561

    UniGene: Hs.489127