Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. CACNG8 Antibody

CACNG8 Antibody

  • 货号：
    CSB-PA823907OA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA823907OA01HU diluted at 1:700 and staining in paraffin-embedded human heart tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CACNG8 Polyclonal antibody
  • Uniprot No.：
    Q8WXS5
  • 基因名：
  • 别名：
    CACNG8; CACNG6; Voltage-dependent calcium channel gamma-8 subunit; Neuronal voltage-gated calcium channel gamma-8 subunit; Transmembrane AMPAR regulatory protein gamma-8; TARP gamma-8
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Peptide sequence from Human Voltage-dependent calcium channel gamma-8 subunit protein (65-83AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CACNG8 Antibody (CSB-PA823907OA01HU)，的标记方式是Non-conjugated。对于CACNG8 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA823907OB01HU CACNG8 Antibody, HRP conjugated ELISA
    FITC CSB-PA823907OC01HU CACNG8 Antibody, FITC conjugated
    Biotin CSB-PA823907OD01HU CACNG8 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits.
  • 基因功能参考文献：
    1. These results indicate that CACNG4, CACNG5, CACNG6 and CACNG8 may contribute to the risk of SCZ. The statistical epistasis identified between CACNG5 and CACNG6 suggests that there may be an underlying biological interaction between the two genes. PMID: 27102562
    2. Patients with Dilated Cardiomyopathy and Sustained Monomorphic Ventricular Tachycardia Show Up-Regulation of KCNN3 and KCNJ2 Genes and CACNG8-Linked Left Ventricular Dysfunction PMID: 26710323
  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic density membrane.
  • 蛋白家族：
    PMP-22/EMP/MP20 family, CACNG subfamily
  • 组织特异性：
    Detected in heart left ventricle.
  • 数据库链接：

    HGNC: 13628

    OMIM: 606900

    KEGG: hsa:59283

    STRING: 9606.ENSP00000270458

    UniGene: Hs.631595