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CACNB1 Antibody

  • 货号：
    CSB-PA004411DSR1HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western blot
      All lanes: CACNB1 antibody at 6.68µg/ml + HepG2 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 66, 58, 54 kDa
      Observed band size: 66 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA004411DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA004411DSR1HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CACNB1 Polyclonal antibody
  • Uniprot No.：
    Q02641
  • 基因名：
  • 别名：
    CAB1 antibody; CACB1_HUMAN antibody; CACNB1 antibody; CACNLB1 antibody; Calcium channel L type beta 1 polypeptide antibody; Calcium channel voltage dependent beta 1 subunit antibody; Calcium channel voltage-dependent subunit beta 1 antibody; CCHLB1 antibody; Dihydropyridine sensitive L type calcium channel beta 1 subunit antibody; MGC41896 antibody; Voltage dependent L type calcium channel beta 1 subunit antibody; Voltage-dependent L-type calcium channel subunit beta-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Voltage-dependent L-type calcium channel subunit beta-1 protein (429-598AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulatory subunit of L-type calcium channels. Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane. Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit. Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit.
  • 基因功能参考文献：
    1. CACNB1, encoding cardiac L-type calcium channel beta 1 subunit, is a potential target for microRNA-328 in transgenic mice. PMID: 21098446
    2. Data show that the length-dependent mechanism of modulating inactivation kinetics of beta(2) calcium channel subunits can be confirmed and extended to the beta(1) calcium channel subunit. PMID: 19821165
  • 亚细胞定位：
    Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    Calcium channel beta subunit family
  • 组织特异性：
    Detected in heart ventricle (at protein level). Isoform 1 and isoform 3 are expressed in brain, heart, spleen, central nervous system and neuroblastoma cells. Isoform 2 is expressed in skeletal muscle.
  • 数据库链接：

    HGNC: 1401

    OMIM: 114207

    KEGG: hsa:782

    STRING: 9606.ENSP00000377840

    UniGene: Hs.635