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CACNA2D2 Antibody

  • 货号：
    CSB-PA080289
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q9NY47
  • 基因名：
  • 别名：
    Alpha 2 delta calcium channel subunit antibody; CA2D2_HUMAN antibody; CACNA2D antibody; Cacna2d2 antibody; Calcium channel, voltage-dependent, alpha 2/delta subunit 2 antibody; Calcium channel, voltage-dependent, alpha 2/delta subunit 2 gene 26 antibody; Calcium voltage gated channel auxiliary subunit alpha2delta 2 antibody; Gene 26 antibody; KIAA0558 antibody; LUAC11.1 antibody; Voltage-dependent calcium channel subunit alpha-2/delta-2 antibody; Voltage-dependent calcium channel subunit delta-2 antibody; Voltage-gated calcium channel subunit alpha-2/delta-2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic Peptide
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis.
  • 基因功能参考文献：
    1. show that the action of alpha2delta2 on tumor development occurs not only through a stimulation of proliferation PMID: 25619833
    2. The investigation of single nucleotide polymorphisms in three genes that have a functional impact on the opioid response: OPRM1, ABCB1 and the calcium channel complex subunit CACNA2D2, is reported. PMID: 23402298
    3. CACNA2D2 deletion/methylation is associated with cervical disease progression. PMID: 21809394
    4. single nucleotide polymorphism identified PMID: 11851383
    5. role in apoptosis in non-small cell lung cancer cells via association with alterations of the intracellular calcium signaling and disruption of mitochondria membrane integrity PMID: 12555074
    6. In mice, targeted disruption of Cacna2d2 led to growth retardation, reduced life span, ataxia, enhanced susceptibility to seizures, and cardiac abnormalities. Cacna2d2 may be involved in hereditary cerebellar ataxias and epileptic disorders in humans. PMID: 15331424
    7. Although transgenic du(2J)/+ mice have a marked reduction in alpha2delta-2 protein, they show no fall in Purkinje somatic calcium currents or increase in cerebellar tyrosine hydroxylase gene expression. PMID: 17135419

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Calcium channel subunit alpha-2/delta family
  • 组织特异性：
    Predominantly present in cerebellar cortex. Present in various lung tumor cell lines, while it is absent in normal lung (at protein level). Highly expressed in heart, lung, testis, pancreas and skeletal muscle. Also expressed in kidney, liver, placenta an
  • 数据库链接：

    HGNC: 1400

    OMIM: 607082

    KEGG: hsa:9254

    STRING: 9606.ENSP00000418081

    UniGene: Hs.476273