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CACNA1B Antibody

  • 货号：
    CSB-PA382497
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using Cav2.2Rabbit pAb diluted at 1:200.
    • Immunohistochemical analysis of paraffin-embedded Mouse Brain Tissue using Cav2.2Rabbit pAb diluted at 1:200.
  • 其他：

产品详情

  • Uniprot No.：
    Q00975
  • 基因名：
  • 别名：
    CACNA1B antibody; CACH5 antibody; CACNL1A5 antibody; Voltage-dependent N-type calcium channel subunit alpha-1B antibody; Brain calcium channel III antibody; BIII antibody; Calcium channel antibody; L type antibody; alpha-1 polypeptide isoform 5 antibody; Voltage-gated calcium channel subunit alpha Cav2.2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic Peptide
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC,ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC IHC-p:1:50-100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by omega-conotoxin-GVIA (AC P01522) (AC P01522). They are however insensitive to dihydropyridines (DHP). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
  • 基因功能参考文献：
    1. Cav2.2 alpha1 subunit alone could form a complex with the AMPAR in heterologous cells. The cell-surface AMPAR was increased by co-expression of Cav2.2 alpha1 subunit. PMID: 29448101
    2. CACNA1B protein expressions in tumorous tissues were correlated with NSCLC patients' clinical characteristics and overall survival. CACNA1B mRNA and protein expression levels were higher in NSCLC tumorous tissues than in nontumorous tissues. PMID: 28127114
    3. These results do not support a causal association between the CACNA1B c.4166G>A; (p.R1389H) variant and M-D. PMID: 26157024
    4. AP-1 binding motifs, present only in exon 37a, enhance intracellular trafficking of exon 37a-containing Ca(V)2.2 to the axons and plasma membrane of rat dorsal root ganglia neurons PMID: 26511252
    5. CACNA1B mutation is linked to unique myoclonus-dystonia syndrome. PMID: 25296916
    6. The first disease connection for Cav2.2 channels [review] PMID: 26218636
    7. The interaction between LC1 and the N-type channel (CaV2.2 channel) was demonstrated. PMID: 24566975
    8. with membrane-localized CaV beta subunits, CaV2.2 channels are subject to Gbetagamma-mediated voltage-dependent inhibition, whereas cytosol-localized beta subunits confer more effective PIP2-mediated voltage-independent regulation PMID: 25225550
    9. Results show that GABA(B) receptors R1 and R2 must be activated for the modulation of N-type (Ca(v)2.2) calcium channels by analgesic alpha-conotoxins Vc1.1 and RgIA. PMID: 22613715
    10. new mechanistic perspectives, and reveal unexpected variations in determinants, underlying inhibition of Ca(V)1.2/Ca(V)2.2 channels by distinct RGK GTPases. PMID: 22590648
    11. Ca(2+) exits the channel through the Cav2.2. PMID: 22491326
    12. polymorphisms and haplotypes in the human CACNA1B gene show significant differences between cerebral infarction and control patients PMID: 21166801
    13. Results suggest that a 39 bp DNA element in the N-type voltage-gated calcium channel alpha1B gene might act as repressor in non-neuronal cells through specific interactions with DNA. PMID: 12018859
    14. molecular dissection of calcium current mechanosensitivity- electrophysiology of N-type calcium channels PMID: 12414690
    15. the C-terminal region of Ca(v)2.2 does not have a critical role in regulation of the calcium channel PMID: 14602720
    16. Cav2.2 alpha2delta auxiliary subunit binds to omega-conotoxins PMID: 15166237
    17. Activation of PKC resulted in its recruitment to and phosphorylation of Ca(V)2.2 channels, but PKC phosphorylation did not dissociate Ca(V)2.2 channel/syntaxin 1A complexes. PMID: 15607937
    18. The Y388S mutation had no effect on current density and cell surface expression of Ca(V)2.2/alpha2delta-2/beta1b channels expressed in human embryonic kidney tsA-201 cells, when equivalent proportions of cDNA were used. PMID: 16627564
    19. Our studies of the e37a/e37b splice site reveal a multifunctional domain in the C-terminus of Ca(V)2.2 that regulates the overall activity of N-type calcium channels in nociceptors. PMID: 16857708
    20. The orientation of the Ca(v)beta subunit relative to the alpha(1)2.2 subunit is critical, and suggests additional points of contact between these subunits are required for Ca(v)beta to regulate channel activity. PMID: 18958281

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  • 相关疾病：
    Dystonia 23 (DYT23)
  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1B subfamily
  • 组织特异性：
    Isoform Alpha-1b-1 and isoform Alpha-1b-2 are expressed in the central nervous system, but not in skeletal muscle or aorta. Expressed in the cerebral white matter, cortex, hippocampus, basal ganglia, and cerebellum.
  • 数据库链接：

    HGNC: 1389

    OMIM: 601012

    KEGG: hsa:774

    STRING: 9606.ENSP00000360406

    UniGene: Hs.495522