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CABIN1 Antibody

  • 货号：
    CSB-PA23399A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, Rat brain tissue
      All lanes: CABIN1 antibody at 3.1µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 247, 238 kDa
      Observed band size: 247 kDa
    • IHC image of CSB-PA23399A0Rb diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA23399A0Rb diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) CABIN1 Polyclonal antibody
  • Uniprot No.：
    Q9Y6J0
  • 基因名：
  • 别名：
    A330070M20Rik antibody; Cabin 1 antibody; CABIN_HUMAN antibody; Cabin1 antibody; CAIN antibody; Calcineurin binding protein cabin 1 antibody; Calcineurin inhibitor antibody; Calcineurin-binding protein cabin-1 antibody; KIAA0330 antibody; PPP3IN antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Rat
  • 免疫原：
    Recombinant Human Calcineurin-binding protein cabin-1 protein (1978-2123AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，CABIN1 Antibody (CSB-PA23399A0Rb)，的标记方式是Non-conjugated。对于CABIN1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA23399B0Rb CABIN1 Antibody, HRP conjugated ELISA
    FITC CSB-PA23399C0Rb CABIN1 Antibody, FITC conjugated
    Biotin CSB-PA23399D0Rb CABIN1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.
  • 基因功能参考文献：
    1. Results indicate an important role for LMP1 and Cabin1 in regulating apoptosis in nasopharyngeal carcinoma cells in response to genotoxic stress. PMID: 23939952
    2. Two new susceptibility loci for amyotrophic lateral sclerosis in the Han Chinese population in chromosome 1, CAMK1G and chromosome 22, SUSD2 and CABIN1. PMID: 23624525
    3. Our findings demonstrate that hCABIN-1 plays a critical role in promoting apoptosis of fibroblast-like synoviocytes and in attenuating inflammation and cartilage and bone destruction in rheumatoid arthritis. PMID: 22275266
    4. NHRD domain of UBN1 as being an essential region for HIRA interaction and chromatin organization by the HUCA complex PMID: 22401310
    5. Data show that, like HIRA, UBN1, and ASF1a, CABIN1 is involved in heterochromatinization of the genome of senescent human cells. PMID: 21807893
    6. CABIN1 may not confer increased susceptibility for schizophrenia in the Japanese population. PMID: 20075944
    7. Crystal structure of the MADS-box/MEF2S domain of human MEF2B bound to a motif of the transcriptional co-repressor Cabin1 and DNA at 2.2 A resolution PMID: 12700764
    8. there is a 13-amino acid region within CN that is essential for the interaction with NFAT and with two other CN-binding proteins, AKAP79 and Cabin-1 PMID: 15671033
    9. Here, we report that Cabin1 has additional CN binding domain in its 701-900 amino acid residues. PMID: 17531200
    10. Cabin1 inhibits p53 function on chromatin in the quiescent state; the presence of inactive p53 on some promoters might allow a prompt response upon DNA damage. PMID: 19668210
    11. the association of CAIN with intracellular domains involved in mGluR/G protein coupling provides a mechanism by which Group I mGluR endocytosis and signaling are regulated PMID: 19717561

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Widely expressed in different tissues.
  • 数据库链接：

    HGNC: 24187

    OMIM: 604251

    KEGG: hsa:23523

    STRING: 9606.ENSP00000263119

    UniGene: Hs.517478