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C3AR1 Antibody

  • 货号：
    CSB-PA060008
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    Q16581
  • 基因名：
  • 别名：
    C3AR1; AZ3B; C3R1; HNFAG09; C3a anaphylatoxin chemotactic receptor; C3AR; C3a-R
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human C3aR.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
  • 基因功能参考文献：
    1. High C3aR1 expression is associated with acute myeloid leukemia-M2. PMID: 25426664
    2. these findings suggest a critical role for C3a through autocrine/paracrine induction of C3aR in the pathogenesis of cigarette smoke-induced sterile inflammation and provide new therapeutic targets for the treatment of emphysema. PMID: 25465103
    3. Medulloblastoma cells express C3aR, and siRNA-mediated knockdown of C3aR inhibits proliferation of these cells in vitro. PMID: 25603857
    4. Observed a positive correlation between the expression of anaphylatoxin-receptors C3aR and C5aR with platelet activation in patients with coronary artery disease. PMID: 25544179
    5. C3aR and CD46 activation via intrinsic generation of their respective ligands is an integral part of human Th1 (but not Th2) immunity. PMID: 24321396
    6. functional regulation of C3aR by NHERFs in human mast cells PMID: 23284683
    7. significantly decreased expression of C3aR mRNA and protein expression in placentas with preeclampsia compared to controls PMID: 22901903
    8. study demonstrates that although C3a causes phosphorylation of its receptor at multiple sites, Ser459, Thr463, Ser465, Thr466 and Ser470 participate in C3aR desensitization PMID: 23077507
    9. Complement C3a receptor activation contributes to the pathogenesis of preeclampsia. PMID: 22868393
    10. a new level of complexity for C3aR regulation PMID: 21799898
    11. shows that both beta-arrestin-1 and beta-arrestin-2 play a novel and shared role in inhibiting G protein-dependent ERK1/2 phosphorylation. These findings reveal a new level of complexity for C3aR regulation by beta-arrestins in human mast cells PMID: 21589858
    12. Mutant gonococci lacking the pilin glycan did not bind to the I-domain when it is in a closed, low-affinity conformation and cannot induce an active conformation to complement receptor 3 during pex cell challenge. PMID: 21371235
    13. Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin. PMID: 12871936
    14. determination of whether the levels of complement factors C3a, C4a, and C5a are elevated at the site of inflammation in chronic obstructive pulmonary disease and in asthma PMID: 15039137
    15. Complement receptor 3 (CR3) is involved in the binding of Leishmania promastigote surface antigen-2 leucine-rich repeat motifs to macrophages, an interaction which can be blocked by anti-CR3 antibodies. PMID: 15067069
    16. C3a receptor is highly expressed in primary renal proximal tubular epithelial cells in studies that define a new pathway by which complement activation may directly modulate the renal response to immunologic injury. PMID: 15356170
    17. C3aR is expressed on plasmacytoid dendritic cells. PMID: 16778800
    18. endothelial cells and subendothelial smooth muscle cells express both C3aR and C5aR PMID: 17234193
    19. C3a receptor may be used as a unique biomarker of diagnosis and disease activity in patients with lupus nephritis. PMID: 17472841
    20. In stenotic valves, expression of C3aR mRNA was upregulated PMID: 17498719
    21. on the basis of the location of C3aR and C5aR, C5aR may play a role in activation of inflammatory cells, whereas C3aR may mediate mucus secretion and mucosal swelling in allergic nasal mucosa, especially severe persistent allergic nasal mucosa PMID: 18538384

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.
  • 数据库链接：

    HGNC: 1319

    OMIM: 605246

    KEGG: hsa:719

    STRING: 9606.ENSP00000302079

    UniGene: Hs.504656