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C2CD3 Antibody

  • 货号：
    CSB-PA673367LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA673367LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA673367LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA673367LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) C2CD3 Polyclonal antibody
  • Uniprot No.：
    Q4AC94
  • 基因名：
    C2CD3
  • 别名：
    C2CD3 antibody; C2 domain-containing protein 3 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human C2 domain-containing protein 3 protein (2079-2265AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，C2CD3 Antibody (CSB-PA673367LA01HU)，的标记方式是Non-conjugated。对于C2CD3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA673367LB01HU C2CD3 Antibody, HRP conjugated ELISA
    FITC CSB-PA673367LC01HU C2CD3 Antibody, FITC conjugated
    Biotin CSB-PA673367LD01HU C2CD3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Component of the centrioles that acts as a positive regulator of centriole elongation. Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation. Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3.
  • 基因功能参考文献：
    1. Our data provide further evidence that mutations in C2CD3 cause a ciliopathy in humans and expand the previously reported phenotype resulting from C2CD3 dysfunction. PMID: 27094867
    2. we uncover that SAS-1 is related to C2CD3, a protein required for complete centriole formation in human cells and affected in a type of oral-facial-digital (OFD) syndrome PMID: 25412110
    3. Loss of C2CD3 results in short centrioles without subdistal and distal appendages. PMID: 24997988
  • 相关疾病：
    Orofaciodigital syndrome 14 (OFD14)
  • 亚细胞定位：
    Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Localizes to centrioles and procentrioles both in interphase and mitosis. Localizes to centriolar satellites, localization is dependent on PCM1 and dynein-mediated retrograde transport. Also localizes to the distal ends of the mother and daughter centrioles.
  • 数据库链接：

    HGNC: 24564

    OMIM: 615944

    KEGG: hsa:26005

    STRING: 9606.ENSP00000323339

    UniGene: Hs.557938