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C1QTNF5 Antibody

  • 货号：
    CSB-PA031979
  • 规格：
    ￥1100
  • 图片：
    • Gel: 10+12%SDS-PAGE, Lysate: 40 μg, Lane: A549 cells, Primary antibody: CSB-PA031979(C1QTNF5 Antibody) at dilution 1/300, Secondary antibody: Donkey anti Guinea pig IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他：

产品详情

  • Uniprot No.：
    Q9BXJ0
  • 基因名：
    C1QTNF5
  • 别名：
    C1QTNF5 antibody; CTRP5 antibody; UNQ303/PRO344 antibody; Complement C1q tumor necrosis factor-related protein 5 antibody
  • 宿主：
    Guinea pig
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human C1QTNF5
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 基因功能参考文献：
    1. High myonectin expression is associated with Type 2 Diabetes. PMID: 29161407
    2. In children adipocyte C1QTNF5 expression is already strongly related to the degree of obesity and is associated with obesity-related AT alterations, systemic CTRP5 serum levels as well as circulating markers of metabolic disease and is positively regulated by TNFalpha in vitro PMID: 28239164
    3. Sequencing of C1QTNF5 revealed 28 unique variants although none showed a statistically significant association with dt-GA when compared with 1000G individuals. PMID: 27149696
    4. Our results provide the first genetic and physiological evidence for CTRP5 as a negative regulator of glucose metabolism and insulin sensitivity. Inhibition of CTRP5 action may result in the alleviation of insulin resistance associated with obesity and diabetes. PMID: 27143553
    5. Late-onset retinal degeneration, proven to have the p.Ser163Arg mutation in C1QTNF5, and asked whether retina-wide sub-RPE deposit was detectable and quantifiable. PMID: 25010528
    6. C1QTNF5 monomers can multimerize into a bouquet-like octadecamer. PMID: 24531000
    7. CTRP-5 might be a novel adipokine that circulates abundantly in human sera. PMID: 23430573
    8. C1QTNF5 retinopathy is an autosomal dominant LORD resulting in a complex ocular phenotype involving the RPE and ciliary epithelium. SD-OCT findings revealed widespread photoreceptor loss and diffuse choroidal thinning. PMID: 23289492
    9. cloning of the bicistronic transcript and characterization of the upstream ORF, MFRP PMID: 11263980
    10. The crystal structure of the trimeric globular domain of human C1QTNF5 at 1.34A resolution reveals unique features of this novel C1q family member. PMID: 22892318
    11. Late-onset retinal degeneration is a progressive degeneration, and anterior segment abnormalities present early. PMID: 22277927
    12. pathogenic role of C1qtnf5 Ser163Arg mutation PMID: 22110650
    13. A physiological function for C1QTNF5 (myonectin) in linking insulin resistance with quantitative changes in mtDNA. PMID: 22031510
    14. This study revealed the presence of a functional promoter for the CTRP5 gene located 5' of its start site. PMID: 20554618
    15. CTRP5 has a role in extracellular deposit formation in late-onset retinal degeneration PMID: 12944416
    16. A single locus at 11q23 is implicated in a complex ocular phenotype involving RPE and CE, tissues of neuroectodermal origin. PMID: 16123441
    17. In this family with a proven mutation in this gene, peripupillary iris atrophy and abnormally long anterior zonular insertions were present before retinal changes and visual loss. PMID: 16376663
    18. L-ORMD is due to insufficient levels of secreted C1QTNF5, compromised RPE cell function resulting from ER retention of the mutant protein or both mechanisms. PMID: 16600989
    19. C1QTNF5 has a role in late-onset retinal degeneration PMID: 17249553

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  • 相关疾病：
    Late-onset retinal degeneration (LORD)
  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    HGNC: 14344

    OMIM: 605670

    KEGG: hsa:114902

    STRING: 9606.ENSP00000402389

    UniGene: Hs.632102