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BRINP3 Antibody

  • 货号：
    CSB-PA755233LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: K562 whole cell lysate, Colo320 whole cell lysate, SH-SY5Y whole cell lysate, A549 whole cell lysate, PC-3 whole cell lysate
      All lanes: BRINP3 antibody at 3.8µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 89, 77 kDa
      Observed band size: 77 kDa
    • IHC image of CSB-PA755233LA01HU diluted at 1:600 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BRINP3 Polyclonal antibody
  • Uniprot No.：
    Q76B58
  • 基因名：
  • 别名：
    BRINP3 antibody; DBCCR1L antibody; DBCCR1L1 antibody; FAM5CBMP/retinoic acid-inducible neural-specific protein 3 antibody; DBCCR1-like protein 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human BMP/retinoic acid-inducible neural-specific protein 3 protein (389-487AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，BRINP3 Antibody (CSB-PA755233LA01HU)，的标记方式是Non-conjugated。对于BRINP3 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA755233LB01HU BRINP3 Antibody, HRP conjugated ELISA
    FITC CSB-PA755233LC01HU BRINP3 Antibody, FITC conjugated
    Biotin CSB-PA755233LD01HU BRINP3 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development.
  • 基因功能参考文献：
    1. the association of serum OGN and FAM5C levels and muscle mass with bone mineral density (BMD), bone turnover markers, and the presence of vertebral fractures (VFs) in 156 postmenopausal women with type 2 diabetes mellitus, is reported. PMID: 27836731
    2. Data show that all the six inflammation-related CpG-SNPs genotypes including IL1B rs16944, IL1R2 rs2071008, PLA2G7 rs9395208, FAM5C rs12732361, CD40 rs1800686, and CD36 rs2065666 were associated with coronary heart disease (CHD), suggesting an important role of inflammation in the risk of CHD. PMID: 27461004
    3. FAM5C is a risk factor for cerebral infarction in type 2 diabetic patients. PMID: 26717922
    4. The results demonstrated that FAM5C is an N-glycosylated protein, and N-glycosylation by UGGT1 is necessary for the secretion of FAM5C. PMID: 28351617
    5. study provides evidence that the BRINP3 polymorphic variant rs1342913 and low level of BRINP3 expression are associated with peri-implantitis, independently from the presence of chronic periodontitis. PMID: 25887438
    6. Data show that family with sequence similarity 5 member C protein FAM5C-positive endothelium expressed intercellular adhesion molecule-1 (ICAM-1) or vascular cell adhesion molecule-1 (VCAM-1). PMID: 25251368
    7. Under expression of BRINP3 is associated with the pathogenesis of ulcerative colitis. PMID: 25171508
    8. findings suggest a protective effect of T allele in women with a history of myocardial infarction (MI;) genotype of FAM5C rs10920501 explained about 7percent of variability of age of onset of coronary heart disease in women who have had an MI; FAM5C remains a gene of interest in a complex disease process PMID: 22013132
    9. expression does not contribute to chronic periodontitis PMID: 22355820
    10. Hypermethylated FAM5C and MYLK in serum are strongly associated with the development of gastric cancer and can be used as potential biomarkers for diagnosis and pre-warning. PMID: 22377736
    11. FAM5C mRNA expression was significantly higher in aggressive periodontitis diseased versus healthy sites, and was found to be correlated to the IL-1beta, IL-17A, IL-4 and RANKL mRNA levels. PMID: 20383335
    12. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    13. Observational study of gene-disease association. (HuGE Navigator) PMID: 20383335
    14. BRINP3 is a mitochondrially localized protein that is selectively up-regulated in human gonadotropinomas; its actions to increase proliferation, migration, and invasion suggest it may play an important role in pituitary tumorigenesis PMID: 17138656
    15. These data implicate FAM5C alleles in the risk of myocardial infarction and suggest further functional studies of FAM5C are required to identify the gene's contribution to atherosclerosis PMID: 18430236
    16. Loss of FAM5C is associated with tongue squamous cell carcinoma. PMID: 19787213
    17. Observational study of gene-disease association. (HuGE Navigator) PMID: 18430236
    18. Genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 17903301

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  • 亚细胞定位：
    Secreted. Mitochondrion.
  • 蛋白家族：
    BRINP family
  • 组织特异性：
    Strongly expressed in oral keratinocytes compared to the weak expression in tongue squamous cell carcinoma (SCC). Expressed in endothelial and aortic smooth muscle cells. Overexpressed in gonadotropinomas compared to normal pituitarie tissues.
  • 数据库链接：

    HGNC: 22393

    KEGG: hsa:339479

    STRING: 9606.ENSP00000356432

    UniGene: Hs.65765