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BRINP1 Antibody

  • 货号：
    CSB-PA006515GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    O60477
  • 基因名：
    BRINP1
  • 别名：
    BMP/retinoic acid-inducible neural-specific protein 1 antibody; BRINP1 antibody; DBC1 antibody; DBC1_HUMAN antibody; DBCCR1 antibody; Deleted in bladder cancer protein 1 antibody; Deleted in bladder cancer protein 1 precursor antibody; FAM5A antibody; IB3089A antibody; Protein FAM5A antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human DBC1
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway.
  • 基因功能参考文献：
    1. Results found that the expression of DBCCR1 is significantly lower in the lung cancer tissues compared with adjacent non-tumor tissues of patients, and correlates with more advanced stages of cancer, and shorter survival of patients. Interestingly, DBCCR1 attenuates the expression of DNMT1, suggesting a reciprocal regulation between genetic silencing of cancer suppressor genes and activating DNA methylation. PMID: 28427182
    2. we found that the SIRT1 modulators AROS and DBC1 have an impact on hsp70 transcription, HSF1 acetylation status, and HSF1 recruitment to the hsp70 promoter PMID: 23349863
    3. DBC1 modulates the stability and function of the nuclear receptor Rev-erb-alpha. PMID: 23398316
    4. the stress-induced DBC1-SIRT1 interaction is important for cell fate determination following genotoxic stress. PMID: 22465953
    5. Rxpression of DBC1 and SIRT1 is a significant prognostic indicator for breast carcinoma patients. PMID: 21056897
    6. High DBC1 expression is associated with breast and lung cancer.. PMID: 20429629
    7. DBCCR1 is involved in the process of bladder tumorigenesis PMID: 12442002
    8. the prevalent inactivation of DBCCR1 seen at the expression level in astrocytomas is not primarily caused by genomic loss of the gene. PMID: 15643521
    9. likely tumor suppressor for NSCLC;silencing through homozygous deletion or methylation of its promoter promotes progression PMID: 15746151
    10. hypermethylation of the DBC1 promoter region is a frequent event during the development of lymphoproliferative malignancies PMID: 18264085

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    BRINP family
  • 组织特异性：
    Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus, prostate, testis and small intestine.
  • 数据库链接：

    HGNC: 2687

    OMIM: 602865

    KEGG: hsa:1620

    STRING: 9606.ENSP00000265922

    UniGene: Hs.532316