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  4. BRD7 Antibody

BRD7 Antibody

  • 货号：
    CSB-PA002803GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9NPI1
  • 基因名：
  • 别名：
    75 kDa bromodomain protein antibody; BP75 antibody; BRD 7 antibody; BRD7 antibody; BRD7_HUMAN antibody; Bromodomain containing 7 antibody; bromodomain containing protein 7 antibody; Bromodomain-containing protein 7 antibody; CELTIX 1 antibody; CELTIX1 antibody; NAG4 antibody; Protein CELTIX-1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Human BRD7
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.
  • 基因功能参考文献：
    1. the transcriptional signature of low BRD7 expressing cells is associated with increased angiogenesis. PMID: 28951988
    2. our data indicated that BRD7 may serve as a tumor suppressor in hepatocellular carcinoma PMID: 26919247
    3. Results demonstrate a novel function of BRD7 in TGF-beta signaling. BRD7 interacts with the Smad tumor suppressor complex, and enhances both DNA-binding ability and transcriptional activity of Smads. BRD7 functions in growth inhibition and tumor suppression partly as a transcriptional co-activator of Smads. PMID: 27270427
    4. Overexpression of BRD7 inhibited cyclin D and myc expression. Our findings are consistent with a tumor suppressor role for BRD7 in lung adenocarcinoma tumorigenesis. PMID: 27580131
    5. the expression of miR-141 in BRD7-overexpressing NPC cells could partially reverse the tumor suppressive effect of BRD7 on cell proliferation and tumor growth in vitro and in vivo. PMID: 27010857
    6. constructed a regulating network of BRD7 downstream genes, and this network suggests multiple feedback regulations of the pathways. Furthermore, we validated BIRC2, BIRC3, TXN2, and NOTCH1 genes as direct, functional BRD7 targets PMID: 26407966
    7. Propose that the balance between BRD7 function and Ras/Raf/MEK/ERK activity is important for determining the outcomes of HCV infection and HCC development. PMID: 26620707
    8. Ectopic expression of BRD7 could significantly inhibit miR-300-promoted proliferation, invasion and epithelial-mesenchymal transition in osteosarcoma. PMID: 26010572
    9. BRD7 promoter hypermethylation is an indicator of well differentiated oral squamous cell carcinomas. PMID: 25743841
    10. Data indicate that bromodomain-containing protein 7 (BRD7) was a direct target of microRNA-410 (miR-410). PMID: 26149213
    11. lower BRD7 expression is an indicator for poor prognosis in patients with osteosarcoma. PMID: 24840027
    12. These results suggested that BRD7 acts as a tumor suppressor in epithelial ovarian cancers PMID: 24198243
    13. Disturbing miR-182 and -381 inhibits BRD7 transcription and glioma growth by directly targeting LRRC4. PMID: 24404152
    14. BRD7-mediated translocation of a subfraction (but not all) of the p85 protein to the nucleus could enhance PI3K signaling. PMID: 24657164
    15. No evidence for breast cancer susceptibility is associated with variants of BRD7. PMID: 22864638
    16. Data show a substantial proportion of germ-line mutations in triple-negative breast cancer (TNBC), with a preponderance of BRCA1 mutations over mutations in BRCA2 or PALB2, but no evidence to implicate BRD7 mutations in the etiology of TNBC. PMID: 23110154
    17. The region from aa219 to aa450 is primarily defined as an atypical nuclear export signal in BRD7. PMID: 21873788
    18. Data indicate that BRD7 may be related to the occurrence, development, and metastasis of lung cancers. PMID: 22008115
    19. miR-200c inhibits the expression of BRD7. MiR-200c regulated the translocation of beta-catenin from the cytoplasm to the nucleus via inhibition of BRD7, resulting in increased expression of its transcriptional target genes, cyclinD1 and c-myc. PMID: 22015043
    20. All-trans retinoic acid enhances brd7 gene expression as HL-60 cells differentiate. PMID: 20561408
    21. as unique regulators of replicative senescence in human cells, both BRD7 and BAF180 regulate p53 transcriptional activity toward a subset of its target genes required for replicative and oncogenic stress senescence induction PMID: 20660729
    22. BRD7 suppresses tumorigenicity by serving as a p53 cofactor required for the efficient induction of p53-dependent oncogene-induced senescence. PMID: 20228809
    23. Regulation of transcription by E1B-AP5 is mediated by complex formation with this protein. PMID: 12489984
    24. BRD7 could up-regulate the expression levels of BRD2 and BRD3 genes in mRNA level to some extent. PMID: 12600283
    25. Expression levels of NAG-7, and BRD7 did not alter in gastric and colorectal cancers. NAG-7 and BRD7 genes may not play role in gastric and colorectal carcinogenesis. PMID: 12918109
    26. BRD7 inhibits G1-S progression by transcriptionally regulating some important molecules involved in ras/MEK/ERK and Rb/E2F pathways. PMID: 15137061
    27. Taken together, the present work shed light on the fact that a novel bromodomain gene, BRD7, is of importance in transcriptional regulation and cellular events including cell cycle. PMID: 16265664
    28. the nuclear localization of BRD7 is critical for the expression of cell cycle related molecules and cell biological function. PMID: 16475162
    29. The results showed that BRD7 could interact with BRD2 and the region from amino acid 430 to 798 of BRD2 was critical for the interaction of BRD2 with BRD7. BRD2 mainly localizes in nucleus and BRD2 has distinct roles in initiating apoptosis. PMID: 16786191
    30. BRD7 promoter demethylation is a prerequisite for high level induction of BRD7 gene expression in human nasopharyngeal carcinoma cells PMID: 18778484
    31. BRD7 is a novel PBAF-specific SWI/SNF subunit that is required for target gene activation and repression in embryonic stem cells PMID: 18809673
    32. c-Myc negatively regulates and Sp1 slightly positively regulate BRD7 promoter activity. PMID: 19111069

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  • 亚细胞定位：
    [Isoform 2]: Nucleus.
  • 数据库链接：

    HGNC: 14310

    KEGG: hsa:29117

    STRING: 9606.ENSP00000378181

    UniGene: Hs.437894