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BRD1 Antibody

  • 中文名称：
    BRD1兔多克隆抗体
  • 货号：
    CSB-PA002799LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA002799LA01HU diluted at 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA002799LA01HU diluted at 1:600 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BRD1 Polyclonal antibody
  • Uniprot No.：
    O95696
  • 基因名：
    BRD1
  • 别名：
    BR140-like protein antibody; BRD1 antibody; BRD1_HUMAN antibody; BRL antibody; Bromodomain and PHD finger-containing protein 2 antibody; Bromodomain containing 1 antibody; Bromodomain-containing protein 1 antibody; BRPF1 antibody; BRPF2 antibody; DKFZp686F0325 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Bromodomain-containing protein 1 protein (756-879AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，BRD1 Antibody (CSB-PA002799LA01HU)，的标记方式是Non-conjugated。对于BRD1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA002799LB01HU BRD1 Antibody, HRP conjugated ELISA
    FITC CSB-PA002799LC01HU BRD1 Antibody, FITC conjugated
    Biotin CSB-PA002799LD01HU BRD1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation.
  • 基因功能参考文献：
    1. There was no association between SNPs in the BRD1 and ZBED4 genes and schizophrenia in the Chinese population. PMID: 29794561
    2. TIMP-4, NT-proANP, NT-proBNP were strongest associated with PAF and AHRE. The discriminatory performance of CHADS2-VASc for PAF was increased by addition of selected biomarkers. PMID: 28431065
    3. Reduced BRD1 expression is associated with Schizophrenia. PMID: 28095495
    4. Findings show that BRD1 primarily binds in close proximity to transcription start sites and regulates expression of numerous genes, many of which are involved with brain development and susceptibility to mental disorders. PMID: 27142060
    5. The PHD finger of BRPF2 can potentially bind DNA non-specifically with an evolutionarily conserved and positively charged surface. PMID: 22820306
    6. BRD1 may have a role in schizophrenia and bipolar affective disorder PMID: 19693800
    7. The association of BRD1 with schizophrenia in a Japanese population, was analysed. PMID: 19908236
    8. These results suggest a general role of BRD1 in the cell and stress that the two BRD1 variants may play different roles in the etiology of psychiatric disease. PMID: 19763615

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  • 亚细胞定位：
    Nucleus. Chromosome.
  • 组织特异性：
    Highly expressed in testis.
  • 数据库链接：

    HGNC: 1102

    OMIM: 604589

    KEGG: hsa:23774

    STRING: 9606.ENSP00000216267

    UniGene: Hs.127950