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BOLL Antibody

  • 货号：
    CSB-PA177370
  • 规格：
    ￥1100
  • 图片：
    • The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA177370(BOLL Antibody) at dilution 1/10. (Original magnification: ×200)
    • The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA177370(BOLL Antibody) at dilution 1/10. (Original magnification: ×200)
  • 其他：

产品详情

  • Uniprot No.：
    Q8N9W6
  • 基因名：
  • 别名：
    Bol (Drosophila boule homolog) like antibody; Bol antibody; Bol boule like antibody; Bol, boule like (Drosophila) antibody; bol, boule-like (Drosophila) antibody; Boll antibody; BOLL_HUMAN antibody; BOULE antibody; Boule like antibody; BOULE, Drosophila, homolog of antibody; Protein boule like antibody; Protein boule-like antibody; Putative uncharacterized protein BOLL antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human BOLL
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:500-1:5000
    IHC 1:5-1:20
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
  • 基因功能参考文献：
    1. hypermethylation of DAZL and BOULE promoters in human sperm is associated with human infertility PMID: 27358391
    2. Our study demonstrated an oncogenic role of BOLL in CRC despite tumor-specific promoter hypermethylation. PMID: 25605553
    3. demonstrate that Boll is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl PMID: 24086306
    4. Assessing the expression of both CDY1 and BOULE by qualitative RT-PCR is a sensitive and feasible test for predicting the presence of sperm cells in testicular tissue biopsies. PMID: 21474125
    5. expression of spermatogenic phenotypes of partial AZFc deletions is independent of the variations in DAZL and BOULE in the Han population PMID: 19342699
    6. BOULE may encode a key conserved switch that regulates progression of germ cells through meiosis in men. PMID: 12499397
    7. Role in spermatogenesis. Decreased DAZ proteins in spermatogenic failure may be due to germ cell loss. Transcription of BOULE, DAZL, and DAZ not altered in degrees of spermatogenic failure. No increase of DAZL or BOULE found in DAZ deletion. PMID: 15066460
    8. Major group of infertile men with meiotic arrest lack BOULE protein and its putative target, CDC25A expression. Spermatogenic failure may arise from factor(s) upstream of BOULE possibly involved in regulating transcription and/or translation of BOULE. PMID: 15070965
    9. BOULE coding sequence mutations are not an important factor in the aetiology of azoospermia. PMID: 15379971
    10. mutations in BOULE can be eliminated as a major cause of impaired spermatogenesis. PMID: 15705409
    11. Among the three BOULE isoforms, B2 might have the major role for meiotic completion. PMID: 17114206
    12. CDC25A is subject to translational control by BOLL, which is an evolutionarily conserved mechanism. PMID: 19417033
    13. human DAZL (deleted in azoospermia-like) functions in primordial germ-cell formation, whereas closely related genes DAZ and BOULE (also called BOLL) promote later stages of meiosis and development of haploid gametes PMID: 19865085

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    RRM DAZ family
  • 组织特异性：
    Testis specific. Not expressed in early embryos, primordial germ cells and spermatogonial cells. First expressed in the cytoplasm of spermatocytes and then persists through meiosis.
  • 数据库链接：

    HGNC: 14273

    OMIM: 606165

    KEGG: hsa:66037

    STRING: 9606.ENSP00000314792

    UniGene: Hs.169797