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BMP5 Antibody

  • 货号：
    CSB-PA001026
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of HuvEC cells using BMP-5 Polyclonal Antibody
    • Western Blot analysis of VEC 293 A549 cells using BMP-5 Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    P22003
  • 基因名：
  • 别名：
    BMP 5 antibody; BMP-5 antibody; Bmp5 antibody; BMP5_HUMAN antibody; Bone morphogenetic protein 5 antibody; MGC34244 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human BMP-5.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation.
  • 基因功能参考文献：
    1. Suggest a significant role of miR-32/BMP5 axis in colorectal cancer tumorigenesis. PMID: 30119170
    2. findings suggested that BMP5 might be a potential prognostic biomarker or therapeutic target for patients with NSCLC PMID: 25994008
    3. Our results showed that ASPN rs13301537 T to C change and variant C genotype may contribute to knee OA risk in a Chinese Han population. PMID: 25030405
    4. Data indicate significant association between the bone morphogenetic protein 5 (BMP5) microsatellite and knee osteoarthritis (OA) in women, but not in men. PMID: 23186552
    5. BMP5, is elevated in the stenotic colon segment of Hirschsprung disease patients, and BMP5 signaling may play a pivotal role in disease development. PMID: 24551273
    6. BMP5 and BMP7, involved in cardiomyocyte differentiation defect PMID: 24384427
    7. CASP3 rs4862396, BMP5 rs3734444 and IRS2 rs7986346 may affect the survival in patients after androgen-deprivation therapy for prostate cancer PMID: 22844442
    8. BMP-5 is expressed in the tubuli of adult kidneys. Its decreased expression in nephrosclerosis along with its regenerative capabilities in HK-2 cells may point to a protective role in hypertensive nephrosclerosis. PMID: 21319131
    9. Taken together, BMP4 and BMP5 simultaneously inhibit the growth and promote migration and invasion of the same pancreatic cells and thus exhibit a biphasic role with both detrimental and beneficial functions in pancreatic cancer progression PMID: 21704030
    10. Variability in gene expression of BMP5 may be an important contributor to osteoarthritis genetic susceptibility PMID: 20021689
    11. The expression signals of BMP-5 mRNA in malignant schwannoma were relatively lower than in benign lesions PMID: 11642720
    12. BMP-5 increases the levels of osteopontin, BMP-2, alkaline phosphatase and core binding factor alpha 1 mRNAs in human periodontal (HPL) ligament cells. PMID: 15516325
    13. BMP5 is expressed in normal synovial tissue and was decreased in osteoarthritis and rheumatoid arthritis. PMID: 16542506
    14. The differential allelic expression (DAE) of BMP5 in human mesenchymal tissues obtained from 16 donors undergoing joint replacement for treatment of osteoarthritis, was examined. PMID: 17220169

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    TGF-beta family
  • 组织特异性：
    Expressed in the lung and liver.
  • 数据库链接：

    HGNC: 1072

    OMIM: 112265

    KEGG: hsa:653

    STRING: 9606.ENSP00000359866

    UniGene: Hs.296648