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BLCAP Antibody

  • 货号：
    CSB-PA006743
  • 规格：
    ￥880
  • 其他：

产品详情

  • Uniprot No.：
    P62952
  • 基因名：
    BLCAP
  • 别名：
    BLCAP; BC10; Bladder cancer-associated protein; Bladder cancer 10 kDa protein; Bc10
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Bc10.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    IF 1:200-1:1000
    ELISA 1:40000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    May regulate cell proliferation and coordinate apoptosis and cell cycle progression via a novel mechanism independent of both p53/TP53 and NF-kappa-B.
  • 基因功能参考文献：
    1. Upregulated miR-9-3p has a positive role in human MTC progression by regulating the growth and apoptosis of cancer cells via targeting BLCAP. PMID: 27938505
    2. Our findings reveal that A-to-I RNA editing events alter the genetically coded amino acid in BLCAP YXXQ motif, which drive the progression of cervical carcinogenesis through regulating STAT3 signaling pathway. PMID: 28455960
    3. data indicates that Blcap is a novel Stat3 interaction partner and suggests a role for Blcap in the Stat3-mediated progression of precancerous lesions to invasive tumors of the bladder PMID: 29190807
    4. the functional association of BLCAP and Rb1 might play important roles in proliferation and apoptosis of HeLa cells. PMID: 26986503
    5. Data show that the RNA-edited bladder cancer associated protein (BLCAP) gene may stably promote cell proliferation. PMID: 25499081
    6. Immunoexpression analysis and prognostic value of BLCAP in breast cancer PMID: 23049907
    7. observed a general decrease in BLCAP-editing level in astrocytomas, bladder cancer and colorectal cancer when compared with the related normal tissues PMID: 19908260
    8. Data show that loss of BLCAP expression is associated with tumor progression. PMID: 19783793
    9. might be a potential tumor suppressor gene in cervical carcinoma. PMID: 16675915
    10. BLCAP may play a role not only in regulating cell proliferation but also in coordinating apoptosis and cell cycle via a novel way independent of p53 and NF-kappaB. PMID: 17031575
    11. Blcap is imprinted in mouse and human brain, but not in other mouse tissues. PMID: 18836209

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  • 亚细胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    BLCAP family
  • 组织特异性：
    Ubiquitous. Expressed in cervical tissues. Down-regulated in bladder invasive carcinoma, renal cell carcinoma and in primary cervical carcinoma.
  • 数据库链接：

    HGNC: 1055

    OMIM: 613110

    KEGG: hsa:10904

    STRING: 9606.ENSP00000362637

    UniGene: Hs.472651