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BICC1 Antibody

  • 货号：
    CSB-PA872503LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA872503LA01HU diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA872503LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BICC1 Polyclonal antibody
  • Uniprot No.：
    Q9H694
  • 基因名：
    BICC1
  • 别名：
    Bic-C antibody; Bicaudal C homolog 1 (Drosophila) antibody; Bicc1 antibody; BICC1_HUMAN antibody; CYSRD antibody; Protein bicaudal C homolog 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Protein bicaudal C homolog 1 protein (682-849AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，BICC1 Antibody (CSB-PA872503LA01HU)，的标记方式是Non-conjugated。对于BICC1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA872503LB01HU BICC1 Antibody, HRP conjugated ELISA
    FITC CSB-PA872503LC01HU BICC1 Antibody, FITC conjugated
    Biotin CSB-PA872503LD01HU BICC1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.
  • 基因功能参考文献：
    1. The s demonstrate that OFD1 cooperates with the mRNA binding protein Bicc1 to functionally control the protein synthesis machinery at the centrosome where also the PIC and eIF4F components were shown to localize in mammalian cells. PMID: 28450740
    2. genetic variants in BICC1 and RASGRF1 are closely associated with high myopia, which appears to be a potential candidate for high myopia in Chinese Han population. PMID: 29044055
    3. Suggest allelic changes in the regulation of the BICC1 gene in amygdala neurones may contribute to mood disorders. PMID: 26440730
    4. Results provide some support for the involvement of BICC1 and PCLO in late-life depressive disorders and preliminary evidence that these genetic variants may also influence brain structural volumes PMID: 26391493
    5. findings identify a role for increased levels of BICC1 in the pathophysiology of depressive behavior PMID: 25178406
    6. identify Bicc1 as a genetic determinant of osteoblastogenesis and BMD and suggest that it does so by regulating Pkd2 transcript levels PMID: 24789909
    7. Polymorphisms in intron 2 of BICC1 are associated with its expression and bone mineral density (BMD) PMID: 24789909
    8. The minor T-allele of BICC1 has a protective role against major depressive disorder and its known structural and functional brain changes. PMID: 22910460
    9. The nonsense mutation identified in BICC1 and associated with cystic renal dysplasia results in a complete loss of Wnt inhibitory activity. The point mutation in the SAM domain results in a 22% loss of activity. PMID: 21922595

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  • 相关疾病：
    Renal dysplasia, cystic (CYSRD)
  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    BicC family
  • 数据库链接：

    HGNC: 19351

    OMIM: 601331

    KEGG: hsa:80114

    STRING: 9606.ENSP00000362993

    UniGene: Hs.100261