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BHMT2 Antibody

  • 货号：
    CSB-PA11829A0Rb
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in: Mouse liver tissue, Raji whole cell lysate
      All lanes: BHMT2 antibody at 3µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 41, 34 kDa
      Observed band size: 41, 34 kDa
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA11829A0Rb at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA11829A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BHMT2 Polyclonal antibody
  • Uniprot No.：
    Q9H2M3
  • 基因名：
    BHMT2
  • 别名：
    BHMT2 antibody; S-methylmethionine--homocysteine S-methyltransferase BHMT2 antibody; SMM-hcy methyltransferase antibody; EC 2.1.1.10 antibody; Betaine--homocysteine S-methyltransferase 2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human, Mouse
  • 免疫原：
    Recombinant Human S-methylmethionine--homocysteine S-methyltransferase BHMT2 protein (1-200AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，BHMT2 Antibody (CSB-PA11829A0Rb)，的标记方式是Non-conjugated。对于BHMT2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA11829B0Rb BHMT2 Antibody, HRP conjugated ELISA
    FITC CSB-PA11829C0Rb BHMT2 Antibody, FITC conjugated
    Biotin CSB-PA11829D0Rb BHMT2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB, IHC, IF
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.
  • 基因功能参考文献：
    1. Our study suggested markers in BHMT/BHMT2 and DMGDH might affect the risk of NSCL/P through pairwise interaction. PMID: 29356306
    2. A three-way interaction among maternal and fetal variants in BHMT2, GSTP1 and GPX3 contribute to congenital heart defects PMID: 26612412
    3. The faster evolutionary rate of BHMT2 overall suggests that selective constraints were reduced relative to BHMT. PMID: 26213999
    4. Multiple SNPs in BHMT and BHMT2 were identified to be associated with the occurrence of infant obstructive heart defects and interaction effects with maternal use of folic acid supplements. PMID: 25846410
    5. No significant level of association was found with cleft lip with or without cleft palate and BHMT2 variants. PMID: 21564312
    6. gene-gene interaction analysis revealed a significant epistatic interaction of BHMT2 (rs673752), PEMT (rs12325817), and PCYT1A (rs712012) with maternal NCL/P susceptibility. PMID: 20662904
    7. Hyperhomocysteinemia, a risk factor for coronary diseases, can be caused by genetic mutations in BHMT2 metabolism. PMID: 12818402
    8. Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase. PMID: 18230605
    9. Common genetic variation in BHMT and BHMT2 and functionally characterized BHMT SNPs. PMID: 18457970

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  • 组织特异性：
    Expressed in liver and kidney and at reduced levels in the brain, heart, and skeletal muscle.
  • 数据库链接：

    HGNC: 1048

    OMIM: 605932

    KEGG: hsa:23743

    STRING: 9606.ENSP00000255192

    UniGene: Hs.114172