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BEX2 Antibody

  • 货号：
    CSB-PA002675GA01HU
  • 规格：
    ￥3,900
  • 其他：

产品详情

  • Uniprot No.：
    Q9BXY8
  • 基因名：
    BEX2
  • 别名：
    BEX2Protein BEX2 antibody; Brain-expressed X-linked protein 2 antibody; hBex2 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Human BEX2
  • 免疫原种属：
    Homo sapiens (Human)
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen Affinity Purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity.
  • 基因功能参考文献：
    1. The study reveals that BEX2 promotes colorectal cancer cell proliferation via the JNK/c-Jun pathway, suggesting BEX2 as a potential candidate target for the treatment of CRC. PMID: 28367093
    2. Bex2 affects the invasion and migration ability of glioma cells by regulating beta-catenin PMID: 25490384
    3. Bex2 overexpression promoted cell migration and invasion in glioma cell lines. PMID: 22907646
    4. Bex2 may be an important player during the development of glioma PMID: 23022184
    5. Both BEX2 and INI1/hSNF5 mainly localized in cell nucleus. PMID: 22698742
    6. BEX2 overexpression was associated with breast cancer. PMID: 21384344
    7. BEX2 has a functional interplay with c-Jun and p65/RelA in breast cancer. PMID: 20482821
    8. These results suggest that the conspicuous expression of the tumor suppressor genes BEX2, IGSF4 and TIMP3 in MLLmu acute myeloid leukemias cell lines is the consequence of altered epigenetic properties of MLL fusion proteins. PMID: 19835597
    9. hBex2 may act as a specific regulator during embryonic development by modulating the transcriptional activity of a novel E-box sequence-binding complex that contains hBex2, LMO2, NSCL2 and LDB1. PMID: 16314316
    10. Correlation between BEX2 expression and mixed lineage leukemia chromosomal aberrations are shown in the cell lines. PMID: 17251904
    11. a NGF/BEX2/NF-kappaB pathway is involved in regulating apoptosis in breast cancer cells and in modulating response to tamoxifen in primary tumors PMID: 17638883
    12. BEX2 is implicated in oligodendroglioma biology. PMID: 19412433

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    BEX family
  • 组织特异性：
    Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Widely expressed in breast cancer cell lines.
  • 数据库链接：

    HGNC: 30933

    OMIM: 300691

    KEGG: hsa:84707

    STRING: 9606.ENSP00000442521

    UniGene: Hs.398989