Your Good Partner in Biology Research

  1. Home
  2. 抗体
  3. 多克隆抗体
  4. BEST2 Antibody

BEST2 Antibody

  • 中文名称：
    BEST2兔多克隆抗体
  • 货号：
    CSB-PA080178
  • 规格：
    ￥880
  • 图片：
    • Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using BEST2 Polyclonal Antibody.
    • Western blot analysis of 1) Mouse Brain Tissue, 2) Rat Brain Tissue using BEST2 Polyclonal Antibody.
  • 其他：

产品详情

  • Uniprot No.：
    Q8NFU1
  • 基因名：
    BEST2
  • 别名：
    BEST2; VMD2L1; Bestrophin-2; Vitelliform macular dystrophy 2-like protein 1
  • 宿主：
    Rabbit
  • 反应种属：
    Mouse,Rat
  • 免疫原：
    Synthetic Peptide
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1000
    IHC 1:200-500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
  • 基因功能参考文献：
    1. BEST2 and BEST4 could be added to the lineage-specific genes of humans intestinal epithelial cells PMID: 24223998
    2. A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. PMID: 22360420
    3. Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon PMID: 20407206
    4. These data suggest that Best2 may play a functional role in the regulation of aqueous flow and drainage in humans. PMID: 20157619
    5. identified three novel VMD2-related human genes demonstrating a high degree of conservation in their respective RFP-TM domains [VMD2L1, VMD2L2, VMD2L3] PMID: 12032738
    6. Results provide evidence that the bestrophins are expressed in pancreatic duct cells and, more specifically, that hBest1 plays a role in the calcium activated chloride channels found in these cells. PMID: 19237432
    7. we examine data obtained from tissue-type and animal models and discuss the current state of bestrophin research, what roles Best2 may play in ocular epithelia and electrophysiology, how perturbation of these functions may result in disease. [REVIEW] PMID: 19398034

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Bestrophin family
  • 组织特异性：
    Mainly confined to the retinal pigment epithelium and colon.
  • 数据库链接：

    HGNC: 17107

    OMIM: 607335

    KEGG: hsa:54831

    STRING: 9606.ENSP00000042931

    UniGene: Hs.435611