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BDH2 Antibody

  • 货号：
    CSB-PA874814LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA874814LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA874814LA01HU at dilution of 1:100
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) BDH2 Polyclonal antibody
  • Uniprot No.：
    Q9BUT1
  • 基因名：
    BDH2
  • 别名：
    3 hydroxybutyrate dehydrogenase type 2 antibody; 3-hydroxybutyrate dehydrogenase type 2 antibody; BDH 2 antibody; BDH2 antibody; BDH2_HUMAN antibody; Dehydrogenase/reductase (SDR family) member 6 antibody; Dehydrogenase/reductase SDR family member 6 antibody; DHRS6 antibody; EFA6R antibody; FLJ13261 antibody; Oxidoreductase ucpA antibody; PRO20933 antibody; R beta hydroxybutyrate dehydrogenase antibody; R-beta-hydroxybutyrate dehydrogenase antibody; SDR15C1 antibody; Short chain dehydrogenase/reductase family 15C member 1 antibody; UCPA OR antibody; UNQ6308 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human 3-hydroxybutyrate dehydrogenase type 2 protein (1-245AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，BDH2 Antibody (CSB-PA874814LA01HU)，的标记方式是Non-conjugated。对于BDH2 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA874814LB01HU BDH2 Antibody, HRP conjugated ELISA
    FITC CSB-PA874814LC01HU BDH2 Antibody, FITC conjugated
    Biotin CSB-PA874814LD01HU BDH2 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Dehydrogenase that mediates the formation of 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin and associates with LCN2, thereby playing a key role in iron assimilation and homeostasis. Plays a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria. Also acts as a 3-hydroxybutyrate dehydrogenase.
  • 基因功能参考文献：
    1. High expression level of BDH2 is associated with esophageal squamous cell carcinoma. PMID: 26799587
    2. intracellular expression in macrophages is downregulated by stress and inflammation PMID: 25762501
    3. BDH2 expression is an independent poor prognostic factor for CN-AML, with an anti-apoptotic role. Patients with high BDH2 expression have relatively shorter overall survival and a low complete response rate. PMID: 23941109
    4. Iron-mediated post-transcriptional regulation of hBDH2 controls mitochondrial iron homeostasis in human cells. PMID: 22527885
    5. Data show that the ketone body metabolizing enzymes BDH1, BDH2, OXCT1 and ACAT1 were expressed at the mRNA and protein level in all glioma cell lines. PMID: 21791085
    6. DHRS6 is an orphan short chain dehydrogenase/ reductase enzyme PMID: 16380372

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Short-chain dehydrogenases/reductases (SDR) family
  • 组织特异性：
    Detected in liver (at protein level).
  • 数据库链接：

    HGNC: 32389

    KEGG: hsa:56898

    STRING: 9606.ENSP00000296424

    UniGene: Hs.124696