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BCKDK Antibody

  • 货号：
    CSB-PA000981
  • 规格：
    ￥880
  • 图片：
    • Western Blot analysis of 3T3 cells using BCKDK Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 K562 Jurkat cells using BCKDK Polyclonal Antibody
  • 其他：

产品详情

  • Uniprot No.：
    O14874
  • 基因名：
  • 别名：
    [3 methyl 2 oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial antibody; [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase antibody; BCKD kinase antibody; BCKD-kinase antibody; BCKD_HUMAN antibody; BCKDHKIN antibody; Bckdk antibody; BCKDKD antibody; BDK antibody; Branched chain alpha keto acid dehydrogenase kinase antibody; Branched chain ketoacid dehydrogenase kinase antibody; Branched-chain alpha-ketoacid dehydrogenase kinase antibody; mitochondrial antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human BCKDK.
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 产品提供形式：
    Liquid
  • 应用范围：
    WB, IHC, IF, ELISA
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex.
  • 基因功能参考文献：
    1. our study indicates that BCKDK promotes colorectal tumorigenesis through up-regulation of the MAPK signaling pathway by phosphorylating MEK at Ser221. PMID: 28501528
    2. There is a relationship between plamsa CST and BCKDK in sepsis patients. PMID: 27773658
    3. Results demonstrate that BCKDK mutations can result in neurobehavioral deficits in humans. PMID: 24449431
    4. This publication is about the mouse gene but contains the 5' sequence of the human gene, including upstream open reading frame information. PMID: 15302860
    5. employment of multidimensional heteronuclear NMR techniques to determine the structure and dynamics of the LBD of the human branched-chain alpha-keto acid dehydrogenase complex (hbLBD) PMID: 11839747

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  • 相关疾病：
    Branched-chain ketoacid dehydrogenase kinase deficiency (BCKDKD)
  • 亚细胞定位：
    Mitochondrion matrix. Mitochondrion.
  • 蛋白家族：
    PDK/BCKDK protein kinase family
  • 组织特异性：
    Ubiquitous.
  • 数据库链接：

    HGNC: 16902

    OMIM: 614901

    KEGG: hsa:10295

    STRING: 9606.ENSP00000219794

    UniGene: Hs.513520