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  4. BCAR1 Antibody

BCAR1 Antibody

  • 货号：
    CSB-PA134376
  • 规格：
    ￥1100
  • 图片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA134376(BCAR1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA134376(BCAR1 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Hela cells, 231 cells, A431 cells, Primary antibody: CSB-PA134376(BCAR1 Antibody) at dilution 1/100, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 4 minutes
  • 其他：

产品详情

  • Uniprot No.：
    P56945
  • 基因名：
  • 别名：
    BCAR 1 antibody; Bcar1 antibody; BCAR1_HUMAN antibody; Breast cancer anti estrogen resistance 1 antibody; Breast cancer anti estrogen resistance 1 protein antibody; Breast cancer anti-estrogen resistance protein 1 antibody; CAS antibody; Cas scaffolding protein family member 1 antibody; CAS1 antibody; Cass1 antibody; Crk associated substrate antibody; Crk associated substrate p130Cas antibody; CRK-associated substrate antibody; CRKAS antibody; FLJ12176 antibody; FLJ45059 antibody; p130cas antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human BCAR1
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated
  • 抗体亚型：
    IgG
  • 纯化方式：
    Antigen affinity purification
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA,WB,IHC
  • 推荐稀释比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion. Implicated in induction of cell migration and cell branching. Involved in the BCAR3-mediated inhibition of TGFB signaling.
  • 基因功能参考文献：
    1. study showed that RBMS1 gene rs7593730 and BCAR1 gene rs7202877 were significantly associated with type 2 diabetes in the Chinese population PMID: 30188962
    2. These results suggest that miR-24-3p functions as a tumor suppressor and the miR-24-3p/p130Cas axis is a novel factor of cancer progression by regulating cell migration and invasion. PMID: 28337997
    3. The s herein prove, for the first time, that the transcriptional repressor Blimp1 is a novel mediator of p130Cas/ErbB2-mediated invasiveness. Indeed, high Blimp1 expression levels are detected in invasive p130Cas/ErbB2 cells and correlate with metastatic status in human breast cancer patients. PMID: 28442738
    4. the results of our study identify BCAR1 as a prognostic biomarker with potential clinical value for risk stratification of ERG-negative prostate cancer. PMID: 29304771
    5. Silencing of p130Cas and inhibition of FAK activity both strongly reduced imatinib and nilotinib stimulated invasion. PMID: 27293031
    6. the p130Cas FAT domain uniquely confers a mechanosensing function. PMID: 28223315
    7. Tyrosine phosphorylation of focal adhesion kinase (FAK) and p130 Crk-associated substrate (CAS) was found to be correlated with pancreatic cancer cell invasiveness. PMID: 27400161
    8. Full-length and truncated p130Cas phosphorylated substrate domain molecules were expressed in breast cancer cells. Breast cancer cells expressing the full-length SD and the functional smaller SD fragment (spanning SD motifs 6-10) were injected into the mammary fat pads of mice. Both the complete and truncated SD significantly increased the occurrence of metastases to multiple organs. PMID: 26867768
    9. Elevated levels of p130Cas is associated with trastuzumab resistance in breast cancer. PMID: 26716506
    10. blockade of GD3-mediated growth signaling pathways by siRNAs might be a novel and promising therapeutic strategy against malignant melanomas, provided signaling molecules such as p130Cas and paxillin are significantly expressed in individual cases. PMID: 27068854
    11. expression quantitative trait loci studies implicate BCAR1 as the causal gene of coronary artery disease Carotid intima-media thickness PMID: 26276885
    12. p130(Cas) exon 1 variants display altered functional properties; shorter 1B isoform exhibited diminished FAK binding activity + reduced cell migration + invasion; longest variant 1B1 exhibited the most efficient FAK binding + greatly enhanced migration PMID: 25805500
    13. these data identify a new p130Cas/Cyclooxygenase-2 axis as a crucial element in the control of breast tumor plasticity. PMID: 23098208
    14. Data introduce hitherto unappreciated paradigms whereby reactive oxygen species can reciprocally regulate the cellular localization of pro- and anti-migratory signaling molecules, p130cas and PTEN, respectively. PMID: 24494199
    15. BCAR1 has a pivotal role in the regulation of tissue homeostasis in pathological conditions such as cancer. (Review) PMID: 25727852
    16. Cas promotes cell migration by linking actomyosin contractions to the adhesion complexes through interaction with Src and the actin cytoskeleton. PMID: 24928898
    17. Collectively, these studies demonstrate that p130Cas acts as a bridging molecule between the Kaposi's sarcoma-associated herpesvirus-induced entry signal complex and the downstream trafficking signalosome in endothelial cells. PMID: 25253349
    18. Our results show that endogenous Cul5 suppresses epithelial cell transformation by several pathways, including inhibition of Src-Cas-induced ruffling through SOCS6 PMID: 24284072
    19. Increased BCAR1 expression is associated with non-small cell lung cancer. PMID: 23904007
    20. P130Cas overexpression synergizes with ErbB2 in mammary cell transformation and promotes ErbB2-dependent invasion. PMID: 23839042
    21. Our results suggest that elevated expression and tyrosine phosphorylation of p130Cas contributes to the resistance to TGF-beta-induced growth inhibition. PMID: 23872147
    22. Data indicate that Abi1 is activated by the c-Abl-Crk-associated substrate (CAS) pathway, and Abi1 reciprocally controls the activation of its upstream regulator c-Abl. PMID: 23740246
    23. p130Cas acts as survival factor by limiting PMA-mediated cell cluster disruption and resulting cell death in HL-60 cells. PMID: 23287717
    24. Disruption of p130Cas attenuates both invasion and migration of the metastatic variant PMID: 23345605
    25. This study identified rs4888378 in the BCAR1-CFDP1-TMEM170A locus as a novel genetic determinant of carotid intima-media thickness and coronary artery disease risk. PMID: 23152477
    26. BCAR1 rs7202877 may mediate its diabetogenic impact through impaired beta-cell function. PMID: 23457408
    27. These results suggest that alteration of morphogenetic pathways due to p130Cas over-expression might prime mammary epithelium to tumorigenesis PMID: 23239970
    28. The aim of this study is to evaluate the role of p130cas, E-cadherin, and beta-catenin expression in patients with non-small cell lung cancer. PMID: 23042269
    29. Study shows that BCAR4 expression identifies a subgroup of ER-positive breast cancer patients without overexpression of ERBB2 who have a poor outcome and might benefit from combined ERBB2-targeted and antioestrogen therapy. PMID: 22892392
    30. BCAR1 is an independent predictor of recurrence following radical prostatectomy for "low risk" prostate cancer. PMID: 22241677
    31. Overexpression of BCAR1 is a predictor of poor prognosis in non-small-cell lung cancer and plays important carcinogenic roles in carcinogenesis. PMID: 22558353
    32. Data show that phosphorylation of Src family kinases and the adaptor protein p130CAS, resulting in actin recruitment and CD36 clustering by 50-60% of adherent beads. PMID: 22106368
    33. These findings reveal an important role of CAS Y12 phosphorylation in the regulation of focal adhesion assembly, cell migration, and invasiveness of Src-transformed cells. PMID: 21937722
    34. a novel function for PTK6 at the plasma membrane PMID: 22084245
    35. p130Cas signaling induces the expression of EGR1 and NAB2 PMID: 22431919
    36. CrkI and p130(Cas) complex regulates the migration and invasion of prostate cancer cells. PMID: 22144090
    37. Immunohistochemical analysis of microarrayed human oral squamous cell carcinoma revealed a significant correlation between uPAR and p130cas expression. PMID: 21630091
    38. The structure of the NSP3-p130Cas complex reveals that this closed conformation is instrumental for interaction of NSP proteins with a focal adhesion-targeting domain present in Cas proteins. PMID: 22081014
    39. Increased p130cas expression is associated with poor clinical outcome in human ovarian carcinoma, and p130cas gene silencing decreases tumor growth through stimulation of apoptotic and autophagic cell death. PMID: 21957230
    40. Cas proteins do not affect E-cadherin transcription, but rather, BCAR1 and NEDD9 signal through SRC to promote E-cadherin removal from the cell membrane and lysosomal degradation. PMID: 21765937
    41. Analyses indicate that p130Cas expression in ErbB2 positive human breast cancers significantly correlates with higher risk to develop distant metastasis, thus underlying the value of the p130Cas/ErbB2 synergism in regulating breast cancer invasion. PMID: 20961652
    42. p130Cas, Src and talin function in both oral carcinoma invasion and resistance to cisplatin. PMID: 21291860
    43. BCAR-1 is a physiological substrate of Syk. PMID: 21047529
    44. CAS plays a role in regulating the extension of cell protrusions and promotes the migration of cancer cells. PMID: 20688056
    45. The crucial interactions required for anti-estrogen resistance occur within the substrate domain of BCAR1 PMID: 19412734
    46. Tyrosine phosphorylation of p130CAS regulates localization and downstream signaling with profound affects on cell movement. PMID: 11779709
    47. Binding of the adapter protein p130Cas to the C-terminal of Pyk2 in cultured human umbilical vein endothelial cells is phosphorylation-independent and is not affected by acute exposure to thrombin. PMID: 11820787
    48. The association of Cas with Wiskott-Aldrich syndrome protein is associated with cell migration in stromal cell-derived factor-1alpha-stimulated Jurkat cells PMID: 12135674
    49. phosphorylation of p130(Cas) can prevent cells from anoikis and contribute to tumor cell anchorage independence and metastasis PMID: 12397603
    50. R-Ras promotes focal adhesion formation by signaling to FAK and p130(Cas) through a novel mechanism that differs from but synergizes with the alpha2beta1 integrin. PMID: 12529399

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  • 亚细胞定位：
    Cell junction, focal adhesion. Cytoplasm. Cell projection, axon.
  • 蛋白家族：
    CAS family
  • 组织特异性：
    Widely expressed with an abundant expression in the testis. Low level of expression seen in the liver, thymus, and peripheral blood leukocytes. The protein has been detected in a B-cell line.
  • 数据库链接：

    HGNC: 971

    OMIM: 602941

    KEGG: hsa:9564

    STRING: 9606.ENSP00000391669

    UniGene: Hs.479747